Some aspects of lipid metabolism in rats treated with anti-insulin serum

Tarrant, M. E.; Thompson, R. H. S.; Wright, Paul J.

doi:10.1042/bj0840006

Cited by 105 publications

(12 citation statements)

References 16 publications

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“…Thus increased utilization of glucose in sheep may be correlated with reduced mobilization of depot fat and vice versa. In contrast to the sevenfold increase in plasma-NEFA level found in rats made diabetic with anti-insulin serum (Tarrant, Thompson & Wright, 1962), the NEFA rise in ruminants was small and not shown at all by one of the cows. This difference may be related to the relative unresponsiveness of ruminants to injected insulin noted by Annison & Lewis (1959).…”

Section: Discussioncontrasting

confidence: 84%

Acute insulin deficiency provoked in sheep and cows by single injections of anti‐insulin serum

Cunningham¹,

Patterson²,

Wright³

1963

The Journal of Physiology

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Section: Discussioncontrasting

confidence: 84%

Acute insulin deficiency provoked in sheep and cows by single injections of anti‐insulin serum

Cunningham¹,

Patterson²,

Wright³

1963

The Journal of Physiology

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“…n-heptane were added and the mixture shaken; 3-0 ml. of the heptane phase was removed and the fatty acids titrated using the modification of Tarrant, Thompson & Wright (1962). Even with these small quantities of plasma the precision of the method was high.…”

Section: Methodsmentioning

confidence: 99%

The Effects of Insulin, Glucagon and Adrenocorticotrophic Hormone on the Plasma Glucose and Free Fatty Acids of the Domestic Fowl

Heald¹,

McLACHLAN²,

Rookledge³

1965

Journal of Endocrinology

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The level of plasma free fatty acids (FFA) in both laying and immature non-laying hens was not markedly decreased by intravenously injected amounts of glucose sufficient to double the level of plasma glucose for 15\p=n-\30min. This was true for fasting and for fed birds. Adrenocorticotrophic hormone (ACTH) given i.v. to laying birds produced a definite increase in the levels of plasma FFA and glucose in doses of 60 i.u./kg. Daily doses of long-acting ACTH given i.m. for 3 days to laying birds produced a marked increase in plasma glucose accompanied by a pronounced fall in plasma FFA. Insulin markedly lowered the plasma glucose level in both mature and immature birds and caused a large and immediate increase in plasma FFA. Glucagon also induced a marked increase in plasma FFA accompanied by a rise in plasma glucose. The effects of insulin and glucagon were not abolished by pretreating the birds with reserpine or hexamethonium bromide. It is concluded that the effect of glucagon on plasma FFA is probably a result of a direct action on avian adipose tissue and that insulin may promote a similar response by an increased release of glucagon from the pancreas.

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“…The free fatty acids (FFA) were extracted from the plasma and estimated by the method of Dole & Meinertz (1960) using the modification of Tarrant, Thompson & Wright (1962). Glucose was estimated both as described by Bell (1957), and by Hugget & Nixon (1957).…”

Section: Methodsmentioning

confidence: 99%

Effect of Gonadal Hormones, Gonadotrophins and Thyroxine on Plasma Free Fatty Acids in the Domestic Fowl

Heald¹,

Rookledge²

1964

Journal of Endocrinology

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The effects of oestrogens, testosterone, thyroxine, avian and mammalian gonadotrophins and of fasting, on the plasma free fatty acid (FFA) levels in the domestic fowl were investigated. Oestrogen treatment increased the levels of plasma FFA simultaneously with those of the total lipids and lipophosphoprotein in the immature fowl. Testosterone and thyroxine decreased the levels of plasma lipids and of lipophosphoprotein in the laying fowl, but had no effect upon the levels of plasma FFA in either the immature or laying fowl. Gonadotrophins were without effect upon the plasma FFA in the immature pullet but increased the levels in laying or moulting birds, the increases being accompanied by marked follicular growth. Fastings increased the level of plasma FFA in immature birds, but decreased the levels of FFA and total lipid in laying birds. Injections of large doses of hog anterior pituitary extract were without effect on the plasma FFA in conscious immature pullets but induced marked increases in the plasma FFA and a gross lipaemia in the rabbit. It is considered that the increases in plasma FFA found when the bird comes into lay are an indirect result of ovarian stimulation by pituitary hormones.

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Some aspects of lipid metabolism in rats treated with anti-insulin serum

Cited by 105 publications

References 16 publications

Acute insulin deficiency provoked in sheep and cows by single injections of anti‐insulin serum

Acute insulin deficiency provoked in sheep and cows by single injections of anti‐insulin serum

The Effects of Insulin, Glucagon and Adrenocorticotrophic Hormone on the Plasma Glucose and Free Fatty Acids of the Domestic Fowl

Effect of Gonadal Hormones, Gonadotrophins and Thyroxine on Plasma Free Fatty Acids in the Domestic Fowl

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