Some Aspects of Lithium in Living Systems

Bach, Ricardo O.

doi:10.1007/978-1-4612-3324-4_1

Cited by 6 publications

(2 citation statements)

References 22 publications

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“…To understand the physiological relevance of these experiments, we have to consider how much Li ϩ accumulates in nerve cells exposed to therapeutic levels of Li ϩ and compare these levels to how much Li ϩ we allowed to accumulate in our cells. Previously, it has been shown that the tissue-to-plasma concentration ratio for Li ϩ is 1.3 (Lam and Christensen, 1992) and that the plasma concentration of Li ϩ -treated patients is between 0.3 and 1.5 mM Li ϩ (Bach, 1990). Therefore, the total intracellular Li ϩ in tissue can reach 2 mM and in some tissue types (i.e., muscle cells), the tissue concentration can exceed these average levels (Komoroski et al, 1997).…”

Section: Discussionmentioning

confidence: 98%

Competition between Li+ and Mg2+ in Neuroblastoma SH-SY5Y Cells: A Fluorescence and 31P NMR Study

Amari

Layden

Nikolakopoulos

et al. 1999

Biophysical Journal

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Because Mg2+ and Li+ ions have similar chemical properties, we have hypothesized that Li+/Mg2+ competition for Mg2+ binding sites is the molecular basis for the therapeutic action of lithium in manic-depressive illness. By fluorescence spectroscopy with furaptra-loaded cells, the free intracellular Mg2+ concentration within the intact neuroblastoma cells was found to increase from 0. 39 +/- 0.04 mM to 0.60 +/- 0.04 mM during a 40-min Li+ incubation in which the total intracellular Li+ concentration increased from 0 to 5.5 mM. Our fluorescence microscopy observations of Li+-free and Li+-loaded cells also indicate an increase in free Mg2+ concentration upon Li+ incubation. By 31P NMR, the free intracellular Mg2+ concentrations for Li+-free cells was 0.35 +/- 0. 03 mM and 0.80 +/- 0.04 mM for Li+-loaded cells (final total intracellular Li+ concentration of 16 mM). If a Li+/Mg2+ competition mechanism is present in neuroblastoma cells, an increase in the total intracellular Li+ concentration is expected to result in an increase in the free intracellular Mg2+ concentration, because Li+ displaces Mg2+ from its binding sites within the nerve cell. The fluorescence spectroscopy, fluorescence microscopy, and 31P NMR spectroscopy studies presented here have shown this to be the case.

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Section: Discussionmentioning

confidence: 98%

Competition between Li+ and Mg2+ in Neuroblastoma SH-SY5Y Cells: A Fluorescence and 31P NMR Study

Amari

Layden

Nikolakopoulos

et al. 1999

Biophysical Journal

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“…Solanaceae are known to have the highest tolerance to lithium and can accumulate more than 1000 mg kg À1 leaf dry matter; by contrast, citrus trees are sensitive to lithium, with levels of 140 to 220 mg kg À1 leaf dry matter being reported as toxic. Even very small quantities of lithium ions in the nutrient solution can rapidly manifest themselves in leaf chlorosis (Bach 1990), as lithium affects chlorophyll content, photosynthesis, respiration and various other metabolic pathways. Although data clearly demonstrate the detrimental effects of lithium to plants, there is evidence that lithium at low concentrations stimulates the growth and development of plants.…”

Section: Effects On Plants Animals and Humansmentioning

confidence: 99%

Lithium

Schäfer¹

2004

Elements and Their Compounds in the Environment

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7Li and23Na NMR studies of transmembrane cation transport mediated by ionophore lasalocid A

Juvvadi

Kalapaty

1998

J. Peptide Sci.

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Ion transport across phospholipid vesicles was studied by 7Li and 23Na-NMR using an aqueous anionic paramagnetic shift reagent, dysprosium nitrilotriacetate [Dy(NTA)2](3-), mediated by ionophores, lasalocid A and A23187. The intra- and extracellular 7Li and 23Na-NMR signals were well separated (20 Hz) at mM concentration of the shift reagent. The observed data on the rate constant for lithium transport across DPPC vesicles at various concentrations of the ionophores indicated that lasalocid A is a more efficient carrier for lithium ion compared with the sodium ion transport by this ionophore, while A23187 was not specific to either of the ions (Li or Na).

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Some Aspects of Lithium in Living Systems

Cited by 6 publications

References 22 publications

Competition between Li+ and Mg2+ in Neuroblastoma SH-SY5Y Cells: A Fluorescence and 31P NMR Study

Competition between Li+ and Mg2+ in Neuroblastoma SH-SY5Y Cells: A Fluorescence and 31P NMR Study

Lithium

7Li and23Na NMR studies of transmembrane cation transport mediated by ionophore lasalocid A

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