Some aspects of the inhibition of the action of antidiuretic hormone by lithium ions in the rat kidney and bladder of the toad Bufo marinus

Abstract

Summary1. The effect of intravenous infusions of various ions on the antidiuretic action of antidiuretic hormone has been studied in rats. 2. Lithium (13 mmol/l.) reversibly inhibits the antidiuretic responses. Similar concentrations of potassium, rubidium, strontium, magnesium, choline and calcium do not. Lithium has a similar effect on the antidiuretic activity of oxytocin.3. The inhibition is not simply related to blood nor whole body lithium concentrations. 4. Lithium (2 mmol/l.) in contact with the serosal surface also inhibits the transport of water facilitated by either 0 5 u/i. antidiuretic hormone or 1 1 mmol/l. cyclic adenosine monophosphate in the isolated toad bladder. 5. Choline (2 mmol/l.) on the serosal surface also inhibits the transport of water facilitated by vasopressin in the toad bladder.

The effect of lithium salts on the urinary excretion of α‐oxoglutarate in man

“…The effect of lithium injection on a-oxoglutarate excretion may also be relevant to other renal actions of lithium, for example the inhibition of the action of vasopressin (Harris & Jenner, 1972).…”

Lithium and the antidiuretic hormone.

“…Lithium can produce a reversible nephrogenic diabetes insipidus in rats and man (Thomsen, 1970;Singer, Rotenberg & Puschett, 1972;Forrest, Cohen, Torretti, Himmelhoch & Epstein, 1974; Harris & Jenner, 1972). This is probably due in part to the inhibition of the renal vasopressin-sensitive adenyl cyclase (Dousa & Hechter, 1970), but there also seems to be evidence for the inhibition of the antidiuretic action of cyclic AMP (Harris & Jenner, 1972;Forrest et aL, 1974), and for an effect of lithium on sodium distribution in the kidney (Jenner & MacNeil, in press).…”

“…This is probably due in part to the inhibition of the renal vasopressin-sensitive adenyl cyclase (Dousa & Hechter, 1970), but there also seems to be evidence for the inhibition of the antidiuretic action of cyclic AMP (Harris & Jenner, 1972;Forrest et aL, 1974), and for an effect of lithium on sodium distribution in the kidney (Jenner & MacNeil, in press). Although in the alcoholanaesthetized rat intravenous lithium has an inhibitory effect on the antidiuretic action of vasopressin within a few minutes of lithium infusion, as found by Harris & Jenner (1972), polyuria in unanaesthetized rats fed or injected with lithium develops only after 1 or 2 days. In man the polyuria does not always occur and it is not simply related to the duration of lithium treatment or to the concentration of lithium in the blood.…”

Phosphomonoesterase hydrolysis of polyphosphoinositides in rat kidney: Properties and subcellular localization of the enzyme system

“…Effects are also observed on the permeability of the epithelial membrane of toad urinary bladder (Bentley & Wasserman, 1972) and the action of antidiuretic hormone (Harris & Jenner, 1972 (0.01-5mM). An apparent stimulation of phosphate release occurred (up to 100% increase at 5mM-cyclic AMP).…”