Some biochemical and haematological changes in rats pretreated with aqueous stem bark extract of <i>Lophira lanceolata</i> and intoxicated with paracetamol (acetaminophen)

Emeka, Patrick; Ozioko, Ikenna Emmanuel; Udem, Ngozi Dorathy; Udem, Samuel Chukwuneke

doi:10.1515/jcim-2014-0007

Cited by 8 publications

(5 citation statements)

References 8 publications

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“…A decrease in the cholesterol level is an indicator of liver healing. This conforms to previous reports on the subject [ 49 , 50 ]. Blood sugar level did not drop after the administration of DHB at a dose of 200 mg/kg while its level dropped slightly in the experimental group ( Table 4 ).…”

Section: Discussionsupporting

confidence: 94%

“…DHB treated rats witnessed an increase in the hematological parameters indicating its strong antioxidant potential compared with ascorbic acid ( Table 6 ). Some other parameters like TLC and PLT counts increased in the paracetamol treated group that contradicts a previous study [ 48 ] while conforms to another study [ 49 ]. DHB treatment lowered the TLC, DLC and PLT counts which indicate its anti-inflammatory effects.…”

Section: Discussioncontrasting

confidence: 69%

See 1 more Smart Citation

Antioxidant, hepatoprotective & nephroprotective potential of a novel synthetic compound 2′, 3′-dihydroxybenzylidene in paracetamol intoxicated rats

Attaullah,

Ullah,

Hussain

et al. 2023

Heliyon

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Section: Discussionsupporting

confidence: 94%

Section: Discussioncontrasting

confidence: 69%

Antioxidant, hepatoprotective & nephroprotective potential of a novel synthetic compound 2′, 3′-dihydroxybenzylidene in paracetamol intoxicated rats

Attaullah,

Ullah,

Hussain

et al. 2023

Heliyon

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“…However, there is significant depletion in levels of direct bilirubin and ALP in group treated with Lophira lanceolata than those of Vitex doniana. These results are in agreement with previous research that Lophira lanceolata and Vitex doniana might have hepatoprotective properties (Ladeji & Okoye, 2008;Patrick et al, 2014;James et al, 2014;Raphael et al, 2020) but in contrast to Abdulrahman et al, (2007) who suggested that Vitex doniana might possess toxic characteristics.…”

Section: Discussionsupporting

confidence: 93%

Therapeutics of L. Lanceolata and V. Doniana on Alcohol Induced Hepatic Pathology

Ujah,

Nenge,

Kassar

et al. 2023

ejtas

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Additive and stimulative properties of alcohol encourage large intake. Notwithstanding, chronic alcohol consumption causes severe hepatic damage, that alters normal biological function of the liver. The aim of this research was to assess the effects of Lophira lanceolata and Vitex doniana extracts on alcohol induced hepatotoxicity using rat model by examining liver serum enzymes (AST, ALT, ALP), lipid peroxidation level, antioxidant enzyme activity and haematological parameters. Thirty Wister rats weighing 70 to 120g were placed in six groups of fives per group. The negative control and treatment groups were familiarized with alcohol (42%) in drinking water before oral administration of 42% consumable alcohol (v/v, 1ml/100g body weight) for nine days. Afterward, the treatment groups were administered 600mg/kg body weight extracts of Lophira lanceolata, Vitex doniana and Vitamin C (as standard drug). Body weight and behavioural characters were monitored during the period. It was observed that, rats in the negative and treatment groups showed significant depletion in weight and negative changes in behaviour. Furthermore, biochemical assessment revealed significant elevated levels of liver serum enzymes (ALT, AST, ALP) activity, total and direct bilirubin, MDA, SOD and CAT while GSH and haematological parameters were significantly depleted at p<0.05. However, the treated groups revealed significant reduction in the liver enzymes, MDA, SOD and CAT while GSH activity and haematological parameters were significantly increased. In conclusion, both extracts have ameliorative and antioxidant properties that could mitigates chronic alcohol hepatotoxicity.

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“…Levels of liver enzyme increase during damage to the liver. An increase in the level of serum bilirubin occurs during breakdown of RBC or as a result of liver damage (Aba et al, 2014). Levels of LDH are observed to monitor liver damage if any.…”

Section: Liver Function Testmentioning

confidence: 99%

Acute and subacute toxicity evaluation of hydroalcoholic extract of Caryota urens leaves in Wistar rats

2020

J app pharm sci

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Caryota urens native to Srilanka and India grows in tropical and subtropical regions. It is rich in nutrition and show pharmacological properties owing to the presence of flavonoids, coumarins, carbohydrates, and amino acids. However, scientific reports which guarantee the safety of C. urens are not available. Therefore, the intention of the current investigation was to assess the potential toxicity of the hydroalcoholic extract of C. urens leaves (CULHA) in Wistar rats. In acute toxicity study, CULHA was administered at a single oral dose of 2,000 mg/kg body weight. In subacute toxicity study, CULHA was administered once a day at three dose levels of 100, 200, and 400 mg/ kg body weight for 28 days. At the end of the treatment, animals were sacrificed; vital organs were removed and examined histopathologically. Blood and serum samples were collected and processed immediately for the analysis of hematological and biochemical parameters. During acute toxicity study, treatment-associated death or manifestation of toxic clinical symptoms were not seen. Furthermore, results of both acute and subacute toxicity group exposed to CULHA did not exhibit significant change in hematology, biochemical parameters, and histopathology. The results demonstrated that CULHA did not possess potential to induce toxicity.

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Some biochemical and haematological changes in rats pretreated with aqueous stem bark extract of Lophira lanceolata and intoxicated with paracetamol (acetaminophen)

Abstract: This study therefore showed that the aqueous stem bark extract of L. lanceolata possesses some active constituents that have antihepatotoxic potentials.

Cited by 8 publications

References 8 publications

Antioxidant, hepatoprotective & nephroprotective potential of a novel synthetic compound 2′, 3′-dihydroxybenzylidene in paracetamol intoxicated rats

Antioxidant, hepatoprotective & nephroprotective potential of a novel synthetic compound 2′, 3′-dihydroxybenzylidene in paracetamol intoxicated rats

Therapeutics of L. Lanceolata and V. Doniana on Alcohol Induced Hepatic Pathology

Acute and subacute toxicity evaluation of hydroalcoholic extract of Caryota urens leaves in Wistar rats

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