Some Biological Leads to Chemotherapy of Blood Protista, Especially Trypanosomatidae

Hutner, S. H.; Fromentin, H; O’Connell, Kathleen

doi:10.1016/b978-1-4832-2787-0.50015-7

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1968

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“…Other advantages of C. jasciculata, i.e., ease of cloning and storage of strains at -20 C, are discussed by Hutner et a1. (7). This report confirms Chesters' observations and reveals that both the charging and transfer reactions in protein synthesis are inhibited by diamidine drugs, quinapyramine, and suramin.…”

Section: Discussionsupporting

confidence: 88%

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Protein Synthesis in Cell‐Free Preparations of *Crithidia fasciculata**

Kahan

Zahalsky

Hutner

1968

The Journal of Protozoology

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SYNOPSIS. Cell‐free preparations from Crithidia jasciculata carried out protein synthesis as measured by 14C‐leucine uptake (optimum ∼ 10 mM Mg++) and poly U‐directed 14C‐phenylalanine uptake (optimum ∼ 16 mM Mg++). Characteristics of the system and sucrose density‐gradient patterns of ribosomes were investigated. The charging and transfer reactions—the 2 main steps in protein synthesis—were inhibited by stilbamidine, hydroxystilbamidine, pentamidine, quinapyramine (Antrycide), and suramin.

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Section: Discussionsupporting

confidence: 88%

“…The chromatoid bodies in such parasitized amoebae also showed signs of degeneration (Figs. 2,3,7 ) . They were very much reduced in size and lacked their typical staining reaction with hematoxylin.…”

mentioning

confidence: 99%