Some biological properties of 2-(4-isobutylphenyl)-propionic acid

Structural Studies for Specific Binding Capacity of β‐Cyclodextrin with Ibuprofen

“…1 Ibu is approved as an oral treatment for mild to moderate pain and for the reduction of fever in adults and in children. 2,3 Because of its safety, Ibu is used widely as a non-prescription analgesic.…”

Immune thrombocytopenia associated with hemorrhagic diathesis due to ibuprofen administration

“…Although ibuprofen has long been used in the treatment of a variety of arthritides since its clinical introduction in 1967, only a few reports have been published describing hematologic complications [1]. The drug has been implicated in the development of agranulocytosis and hemolytic anemia [5,6,[8][9][10].…”

Unidirectional Inversion of Ibuprofen in Caco-2 Cells: Developing a Suitable Model for Presystemic Chiral Inversion Study

“…Assuming that (Ϫ) R ibuprofen undergoes no other metabolism except for inversion, the elimination constant can be approximately regarded as the inversion rate constants (k inv ). The fraction inverted (F i ) when (Ϫ) R ibuprofen administered was calculated based on the principles that assuming no other metabolism occurred in Caco-2 cells (S-ibuprofen undergo negligible metabolism in Caco-2 cells evidenced from the fact that no significant decrease of concentration was observed during the 120 h coincubation), the inversion ratio can be calculated from the equation as follows: (1) where AUCS is the AUC of the S-enantiomer while AUCR is the AUC of the R-enantiomer following incubation with Renantiomer. For racemic ibuprofen investigation, the inversion ratio was calculated based on the principles discussed by Frihmat 16) fitted to the in vitro model as follows: (2) where AUCS and AUCT/2 indicated the AUC of the S-enantiomer and half of AUC sum of both enantiomers following incubation with racemic ibuprofen.…”

“…Since its first observance in 1967 by Adams,1) the pathway and involved biochemical mechanisms of ibuprofen inversion had been fundamentally elucidated in the past forty years. But reports concerning the site of inversion in the current literature still seemed to be contradictory.…”