Some Characteristics of Hemagglutination of Certain Strains of "IBV-like" Virus

Kaye, Harold S.; Dowdle, Walter R.

doi:10.1093/infdis/120.5.576

Cited by 67 publications

(72 citation statements)

References 12 publications

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“…Similar observations were reported for HCV OC43 and BCV. However, the unstable hemagglutination/ hemadsorption pattern could not be linked to the presence of a specific receptor-destroying enzyme (11,21,22). For further studies we screened erythrocytes of different origin for hemagglutination by coronaviruses.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore we reexamined the possibility that coronaviruses might recognize cell receptors similar to those of influenza viruses. Earlier studies (11) revealed that treatment of erythrocytes with Vibrio cholerae neuraminidase (EC 3.2.1.18) did not remove cell receptors recognized by HCV OC38 and OC43, and no neuraminidase activity was found to be associated with HCV OC43 (12,13). It was also reported that the hemagglutination pattern of avian infectious bronchitis virus and of a mouse enteric coronavirus was unstable at elevated temperature, suggesting the presence of a receptordestroying enzyme (14,15).…”

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confidence: 99%

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Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses.

Vlasak

Luytjes

Spaan

et al. 1988

Proc. Natl. Acad. Sci. U.S.A.

339

333

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Human coronavirus OC43 and bovine coronavirus elute from agglutinated chicken erythrocytes when incubated at 37TC, suggesting the presence of a receptordestroying enzyme. Moreover, bovine coronavirus exhibits an acetylesterase activity in vitro using bovine submaillary mucin as substrate similar to the enzymatic activity found in influenza C viruses. Furthermore, pretreatment of erythrocytes with either influenza C virus or bovine coronavirus eliminates subsequent binding and agglutination by either coronaviruses or influenza C virus, whereas binding of influenza A virus remains intact. In addition, hemag-utination by coronaviruses can be inhibited by pretreatment of erythrocytes with Arthrobacter ureafaciens or Closrtidimwperfringens neuraminidase or by addition of sialic acid-containing gangliosides. These results suggest that, like influenza C viruses, human coronavirus OC43 and bovine coronavirus recognize 0-acetylated'sialic acid or a similar derivative as cell receptor.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses.

Vlasak

Luytjes

Spaan

et al. 1988

Proc. Natl. Acad. Sci. U.S.A.

339

333

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“…Previous reports have shown the presence in humans of antibody to animal coronaviruses (Hartley et at., 1964;Miller & Yates, 1968) and the existence of serological cross-reactions among and between human and animal coronavirus strains (Mclntosh et aL, 1967a, b;Kaye & Dowdle, 1969;Bradburne, 1970;Pedersen et al, 1978). The detection in human sera of antibody to NCDCV suggested the existence of an enteric coronavirus in man (Sharpee & Mebus, 1975).…”

Section: Discussionmentioning

confidence: 99%

“…Both coronaviruses, grown in MA-321 cell cultures, were tested by the microtitre method for HA against rat (Sprague-Dawley and Wistar), grivet, human 'O', 1-day-old chick and chicken erythrocytes at 4 °C, room temperature and 37 °C. A speetrophotometrically standardized 0.4 % suspension of mammalian and a 0.5 % suspension of 1-day-old chick and chicken red blood cells in PBS, were used for the HA reaction (Kaye & Dowdle, 1969). After initial experiments, the HA reaction for both viruses was routinely performed at room temperature using chicken erythrocytes.…”

Section: Methodsmentioning

confidence: 99%

Antigenic and Biological Relationships between Human Coronavirus OC43 and Neonatal Calf Diarrhoea Coronavirus

Gerna¹,

Cereda²,

Revello³

et al. 1981

Journal of General Virology

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SUMMARYMonospecific antisera were prepared in mice to human coronavirus OC43 and neonatal calf diarrhoea coronavirus (NCDC V) which had been previously adapted to growth in suckling mouse brain. Brain suspension from infected suckling mice was used as immunogen. The antigenic relationship between OC43 and NCDCV was studied by the indirect immunoperoxidase antibody technique, by the haemagglutination-inhibition (HI) test and a new infectious centre-reduction neutralization test. In mouse immune sera, a two-way cross-reaction between OC43 and NCDCV was detected. However, the antigenic relationship appeared to be closer for internal (as shown by immunoperoxidase staining) as compared to surface antigens (as shown by HI and neutralization). In primary infections of natural hosts there was a high degree of cross-reactivity between the two coronavirus strains for both surface and internal antigens, and homologous and heterologous titres were consistently within an eightfold dilution difference by all tests. Most human adults and calves had antibody to both OC43 and NCDCV and geometric mean titres of homologous antibody were higher than titres of heterologous antibody. Although OC43 and NCDCV share antigenic determinants, they possessed several different biological properties, including plaque morphology by the infectious centre assay, agglutination of 1-day-old chick erythrocytes and resistance of haemagglutinin to physical and chemical treatments.

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“…The OC 43 strain had been isolated by McIntosh et al (1967a) and had been shown to be indistinguishable from another isolate named OC 38. The OC43 strain adapted to the brain ofsuckling mice (McIntosh, Becker & Chanock, 1967 b) was used for haemagglutination inhibition tests as described by Kaye & Dowdle (1969).…”

Section: Methodsmentioning

confidence: 99%

Coronavirus antibody titres in sera of healthy adults and experimentally infected volunteers

Bradburne

Somerset

1972

J. Hyg.

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SUMMARYSix coronaviruses isolated in the U.S.A. have been inoculated into volunteers and all produced colds. Between 10 and 20 % of infected volunteers developed heterologous antibody responses after these and other experimental infections with coronaviruses. The haemagglutination-inhibition test with the OC43 virus strain was found to detect antibody rises after infection with a variety of strains.Studies on normal adult sera taken between 1965 and 1970 revealed a high frequency of neutralizing antibody to one strain (229E) and a frequency of HI antibody to strain OC43 which fluctuated from year to year. Complement-fixing antibodies to these two viruses were also found, revealing an apparent increase in the activity of coronaviruses in the general population of the U.K., during the winter of 1968-9.

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Some Characteristics of Hemagglutination of Certain Strains of "IBV-like" Virus

Cited by 67 publications

References 12 publications

Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses.

Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses.

Antigenic and Biological Relationships between Human Coronavirus OC43 and Neonatal Calf Diarrhoea Coronavirus

Coronavirus antibody titres in sera of healthy adults and experimentally infected volunteers

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