Some Clinical Implications of Adrenergic Receptors in the Urinary Tract

Caine, Marco; Raz, Shlomo

doi:10.1001/archsurg.1975.01360090017003

Cited by 60 publications

(21 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Estrogen and progesterone, in particular, are known to a ect most components that contribute to urethral closure in many ways, such as biomechanical softening of the tissues, interaction with estrogen receptors, modi®cation of adrenergic receptor density and innervation, changes to electrophysiological properties of smooth muscle, inhibition of extraneuronal uptake of catecholamines, modi®cation of cholinergic responses and interaction with prostaglandins. 2,11 In clinical practice, however, the reported e ects of estrogen treatment, in terms of cure rates and urethral pro®le measurements, are con¯icting. 3,4,12,13 These aspects con®rm, as is known, that UPP is of limited practical value in studying continence or in the follow-up of incontinent patients undergoing estrogen therapy.…”

Section: Discussionmentioning

confidence: 99%

The feasibility of urethral color ultrasound imaging in the diagnosis of female intrinsic sphincter deficiency: preliminary results

et al. 2002

View full text Add to dashboard Cite

Study design: Prospective study. Objectives: To evaluate the feasibility of color ultrasound imaging of the urethra in association with UPP to diagnose intrinsic sphincter de®ciency (ISD). Setting: Italy. Methods: We studied a group of 13 normal female volunteers (mean age 29 years) during the estrogenic phase and a group of 15 patients (mean age 63.9 years) with ISD. All patients and normal volunteers underwent color ultrasound imaging using a 4 ± 7 MHz convex broad band transducer. Translabial sagittal scans of the urethra were obtained. The color ultrasound parameters were optimized for detection of parenchymal slow¯ows. A subjective score of the degree of vascularization along the entire urethra was established as follows: (a) minimal or absent (1), (b) poor (2), (c) moderate (3), (d) good (4). Statistical analysis, using the nonparametric Mann-Whitney rank sum test, was carried out to determine di erences of ultrasound scores between volunteers and patients. Results: The statistical evaluation showed that the di erences between the ultrasound scores in the two groups was statistically signi®cant (P50.001). Conclusion: We a rm that color ultrasound imaging of the urethra seems to be feasible and useful in association with UPP in the diagnosis of ISD even if this echographic investigation needs further observations.

show abstract

Section: Discussionmentioning

confidence: 99%

The feasibility of urethral color ultrasound imaging in the diagnosis of female intrinsic sphincter deficiency: preliminary results

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Schreiter et al [ 19761 found that estrogen has an alpha-receptor sensitizing characteristic. Caine and Raz [1975] found a direct influence on the urethral muscles, produced by a modification of the adrenergic receptors. Furthermore they found that progesterone facilitates or increases P-adrenergic sensitivity in the urethra.…”

Section: Urethral Pressure: Functional Considerationsmentioning

confidence: 92%

Urethral pressure variations in healthy and incontinent women

Sørensen

1992

Neurourology and Urodynamics

View full text Add to dashboard Cite

“…Early studies employed agents such as phentolamine [35] , phenoxybenzamine [36][37][38] , or ␣ -difluoromethylornithine [37] . The nonspecific alpha-blocking agents available in the early 1980s had side effect profiles that severely limited their clinical utility for treating patients with symptoms of prostatitis [39] .…”

Section: Uncontrolled and Small Prospective Studies Of Alpha Blocker mentioning

confidence: 99%

Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Role of Alpha Blocker Therapy

et al. 2007

View full text Add to dashboard Cite

Introduction: This article reviews the rationale and data supporting alpha blocker therapy for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), the most common and difficult prostatitis syndrome. Methods: Systematic review identified ten clinical trials evaluating alpha blocker therapy for patients with CP/CPPS, including five open-label or small prospective studies and five double-blinded and placebo-controlled clinical trials. Results: Encouraging results in uncontrolled and small clinical trials led to the development of reasonably powered, double-blinded, placebo-controlled, randomized clinical trials evaluating terazosin, doxazosin, tamsulosin, and alfuzosin. Conclusions: Current data suggest that treatment-naïve and/or newly diagnosed patients appear more likely to respond than long-term, chronic refractory patients. Longer courses of treatment (12 weeks to 6 months) appear superior to shorter courses, and less selective agents appear superior to more selective alpha₁ blockers. These observations outline important questions that must be answered to define optimal treatment strategies for patients with CP/CPPS.

show abstract

Some Clinical Implications of Adrenergic Receptors in the Urinary Tract

Cited by 60 publications

References 22 publications

The feasibility of urethral color ultrasound imaging in the diagnosis of female intrinsic sphincter deficiency: preliminary results

The feasibility of urethral color ultrasound imaging in the diagnosis of female intrinsic sphincter deficiency: preliminary results

Urethral pressure variations in healthy and incontinent women

Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Role of Alpha Blocker Therapy

Contact Info

Product

Resources

About