Some considerations on biomaterials and bone

Zaffe, Davide

doi:10.1016/j.micron.2005.05.008

Cited by 37 publications

(25 citation statements)

References 47 publications

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“…The orientation of the needle-shaped plates observed in this study is therefore similar to that of trabecular bone. 30,31,40 The similarity in crystalline arrangement and morphology between plate-type apatite in bone and biomimetic apatite reported in other studies 10,11,28,30,31,[41][42][43] also supports the principle of similitude in apatite formation.…”

Section: Discussionsupporting

confidence: 57%

Ultrastructural analyses of nanoscale apatite biomimetically grown on organic template

et al. 2008

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The ultrastructure of nanoscale apatite biomimetically formed on an organic template from a supersaturated mineralizing solution was studied to examine the morphological and crystalline arrangement of mineral apatites. Needle-shaped apatite crystal plates with a size distribution of ~100 to ~1000 nm and the long axis parallel to the c axis ([002]) were randomly distributed in the mineral films. Between these randomly distributed needle-shaped apatite crystals, amorphous phases and apatite crystals (~20-40 nm) with the normal of the grains quasi-perpendicular to the c axis were observed. These observations suggest that the apatite film is an interwoven structure of amorphous phases and apatite crystals with various orientations. The mechanisms underlying the shape of the crystalline apatite plate and aggregated apatite nodules are discussed from an energy-barrier point of view. The plate or needle-shaped apatite is favored in single-crystalline form, whereas the granular nodules are favored in the polycrystalline apatite aggregate. The similarity in shape in both singlecrystalline needle-shaped apatite and polycrystalline granular apatite over a wide range of sizes is explained by the principle of similitude, in which the growth and shape are determined by the forces acting upon the surface area and the volume.

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Section: Discussionsupporting

confidence: 57%

Ultrastructural analyses of nanoscale apatite biomimetically grown on organic template

et al. 2008

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“…However, the life quality of patients could be improved by using biomaterials that may interact with biological systems having minimal flaws and long service; therefore, they may be used for manufacturing human body implants [4]. Alloplastic implants using synthetic biomaterials have become a good choice because of their high immunological compatibility, easy way to obtain, and high availability in the materials commercial market [5]. Nevertheless, materials used in vivo must have similar characteristics and properties with respect to bone hosting tissue, and should also promote osseointegration; this means, to reach a direct, structural and functional connection between bone and implant surface [6].…”

Section: Introductionmentioning

confidence: 99%

Osseointegration improvement by plasma electrolytic oxidation of modified titanium alloys surfaces

Echeverry‐Rendón

Galvis

Giraldo

et al. 2015

J Mater Sci: Mater Med

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Titanium (Ti) is a material frequently used in orthopedic applications, due to its good mechanical properties and high corrosion resistance. However, formation of a non-adherent fibrous tissue between material and bone drastically could affect the osseointegration process and, therefore, the mechanical stability of the implant. Modifications of topography and configuration of the tissue/ material interface is one of the mechanisms to improve that process by manipulating parameters such as morphology and roughness. There are different techniques that can be used to modify the titanium surface; plasma electrolytic oxidation (PEO) is one of those alternatives, which consists of obtaining porous anodic coatings by controlling parameters such as voltage, current, anodizing solution and time of the reaction. From all of the above factors, and based on previous studies that demonstrated that bone cells sense substrates features to grow new tissue, in this work commercially pure Ti (c.p Ti) and Ti6Al4V alloy samples were modified at their surface by PEO in different anodizing solutions composed of H2SO4 and H3PO4 mixtures. Treated surfaces were characterized and used as platforms to grow osteoblasts; subsequently, cell behavior parameters like adhesion, proliferation and differentiation were also studied. Although the results showed no significant differences in proliferation, differentiation and cell biological activity, overall results showed an important influence of topography of the modified surfaces compared with polished untreated surfaces. Finally, this study offers an alternative protocol to modify surfaces of Ti and their alloys in a controlled and reproducible way in which biocompatibility of the material is not compromised and osseointegration would be improved.

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“…Rodriguez-Lorenzo et al [30] prepared apatite suspensions containing soluble starch, and utilized the swelling of starch to form pores, followed by sintering at 1,100°C and granulation. In brief, research related to the production of calcium phosphate granules is gaining pace in recent years [31][32][33][34][35][36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

“…Pharmaceutical granules [52][53][54][55] typically assume sizes between 0.2 and 4.0 mm, and in orthopedic surgery granules between 1 and 2 mm [36,38], whereas in periodontal surgery granule sizes of 0.25-1 mm are preferred [56]. Therefore, it would not have been unusual to inspire from the granulation processes and procedures of pharmaceutical industry to produce CaP granules for skeletal repair and biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Preparation of porous apatite granules from calcium phosphate cement

Taş

2007

J Mater Sci: Mater Med

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A versatile method for preparing spherical, micro-and macroporous (micro: 2-10 and macro: 150-550 lm pores), carbonated apatitic calcium phosphate (Ap-CaP) granules (2-4 mm in size) was developed by using NaCl crystals as the porogen. The entire granule production was performed between 21 and 37°C. A CaP cement powder, comprising a-Ca 3 (PO 4 ) 2 (61 wt.%), CaH-PO 4 (26%), CaCO 3 (10%) and precipitated hydroxyapatite, Ca 10 (PO 4 ) 6 (OH) 2 (3%), was dry mixed with NaCl crystals varying in size from 420 lm to 1 mm. Cement powder (35 wt.%) and NaCl (65 wt.%) mixture was kneaded with an ethanol-Na 2 HPO 4 initiator solution, and the formed dough was immediately agitated on an automatic sieve shaker for a few minutes to produce the spherical granules. Embedded NaCl crystals were then leached out of the granules by soaking them in deionized water. CaP granules were micro-and macroporous with a total porosity of 50% or more. Granules were composed of carbonated, poorly crystallized, apatitic CaP phase. These were the first spherical and porous CaP granules ever produced from a self-setting calcium phosphate cement. The granules reached their final handling strength at the ambient temperature through the cement setting reaction, without having a need for sintering.

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Some considerations on biomaterials and bone

Cited by 37 publications

References 47 publications

Ultrastructural analyses of nanoscale apatite biomimetically grown on organic template

Ultrastructural analyses of nanoscale apatite biomimetically grown on organic template

Osseointegration improvement by plasma electrolytic oxidation of modified titanium alloys surfaces

Preparation of porous apatite granules from calcium phosphate cement

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