Some Contributions of Immunology to the Study of Proteins

Treffers, Henry P.

doi:10.1016/s0065-3233(08)60255-7

Cited by 25 publications

(4 citation statements)

References 140 publications

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“…The suggestions, originating with Halliburton in 1887 (cited in reference 12) that some of the circulating proteins, particularly beta and gamma globulins, may be produced by lymphoid tissue, spleen, or reticuloendothelial (extrahepatic) phagocytes have been made by several other authors (6,(13)(14)(15)(16)(17)(18)(19)(20)(21) and reviewed by White and Gordon (12). These suggestions are based largely on the results of electrophoretic or immunological studies.…”

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confidence: 99%

PLASMA AND TISSUE PROTEINS PRODUCED BY NON-HEPATIC RAT ORGANS AS STUDIED WITH LYSINE-ϵ-C14

Miller

Bly

Bale

1954

Journal of Experimental Medicine

102

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A recent report (1) presented direct evidence for the dominant role of the liver in the production of plasma proteins, as studied in the isolated peffused organ, and compared the results with those obtained in intact living animals.This paper describes an attempt to assess the comparative role of the extrahepatic tissues in plasma protein synthesis. For this purpose, ten "carcass ''t perfusions have been carried out, using in general the same apparatus, lysinee-Ct% and methods previously described (1). Here again comparisons are made with results obtained in intact animals. The data show that the extrahepatic tissues produce but very small amounts of plasma protein, entirely of the nature of globulins, despite the incorporation of large amounts of lysine-e-C ~ into tissue protein.In order to define more dearly the plasma proteins produced by the nonhepatic tissues, plasma from eviscerated surviving rats injected with lysine-~-C u has been fractionated by the technique of preparative zone electrophoresis (2). The non-hepatic tissues of the eviscerated rat incorporate the labeled lysine chiefly into the plasma proteins with the mobility of the gamma globulins. The

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PLASMA AND TISSUE PROTEINS PRODUCED BY NON-HEPATIC RAT ORGANS AS STUDIED WITH LYSINE-ϵ-C14

Miller

Bly

Bale

1954

Journal of Experimental Medicine

102

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“…From the standpoint of the immunochemist, however, the assay of blood group activity by the hemagglutination inhibition technic was relatively unsatisfactory, because of the large errors involved and the consequent difficulty of comparing the activity of various preparations with one another and of correlating activity and other chemical properties. If a precipitin reaction between A substance and homologous anti-A formed in humans could be demonstrated, it would immediately be possible to apply the powerful technics of quantitative immunochemistry (cf., 16,25,26,33,51) to the assay of these substances and to obtain estimates of their purity. Three important developments took place which prepared the way for the demonstration of such a precipitin reaction.…”

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Immunochemical Studies on Blood Group Substances 1

Kabat¹

1949

Bacteriological Reviews

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“…In either case, they may not specifically inhibit enzyme activity but may simply reduce the effective surface relationship between enzyme and substrate. (See review in Taliaferro (53) for a discussion of the mode of action of precipitins in immunity to nematodes; Dukes (25) and Smith and Lindsley (46) for examples of antibodies affecting bacterial enzymes; and general reviews in Treffers (67) and Sevag (44)).…”

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The Inhibition of Reproduction of Parasites by Immune Factors 1

Taliaferro¹

1948

Bacteriological Reviews

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First of all, I should like to express my great appreciation for the invitation to give this lecture. I should have considered it a great honor to give any one of this newly organized series, but I feel particularly honored in being selected to give the lecture named after Ludvig Hektoen. Beside my respect for Dr. Hektoen as a scientist, which I share with all of you, I count among the great benefits of moving to Chicago the fact that it has given me some twenty years of his friendship and gracious advice. Today, I should like to present some of the work on the inhibition of reproduction of the animal parasites in the body by immune factors. I hope to demonstrate some of the advantages of the protozoa and worms for this type of study. The subject has been of interest to me and my co-workers for about 25 years, but it is still a very incomplete picture. Although immune factors are frequently assumed to inhibit the rate of reproduction of invading organisms in vivo, there are only a few instances in which 1 An amplification of the Ludvig Hektoen Lecture delivered before the Society of American Bacteriologists,

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Some Contributions of Immunology to the Study of Proteins

Cited by 25 publications

References 140 publications

PLASMA AND TISSUE PROTEINS PRODUCED BY NON-HEPATIC RAT ORGANS AS STUDIED WITH LYSINE-ϵ-C14

PLASMA AND TISSUE PROTEINS PRODUCED BY NON-HEPATIC RAT ORGANS AS STUDIED WITH LYSINE-ϵ-C14

Immunochemical Studies on Blood Group Substances 1

The Inhibition of Reproduction of Parasites by Immune Factors 1

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