Some Dietary Fibers Reduce the Absorption of Carotenoids in Women

Riedl, Judith; Linseisen, Jakob; Hoffmann, Jürgen; Wolfram, G.

doi:10.1093/jn/129.12.2170

Cited by 228 publications

(167 citation statements)

References 42 publications

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“…Moreover, differences in bioavailability could distort any direct relationship between intakes and intestinal absorption. For example, b-carotenoid, but not a-tocopherol, absorption is reduced by some dietary fibres (Riedl et al, 1999).…”

Section: Dietary Antioxidants In Diabetes Mellitusmentioning

confidence: 99%

Oxidative stress status in patients with diabetes mellitus: relationship to diet

et al. 2003

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Objective: To investigate the relationship between dietary intakes and in vivo oxidative stress (OS) status in diabetic patients. Design: Case-control study. Setting: Outpatient-Clinic and Laboratory Endocrinology, University Antwerp. Subjects and methods: A total of 30 patients (24 type 1 diabetes mellitus (T1DM)/6 type 2 diabetes mellitus (T2DM) were asked to complete a 2 weekdays+1weekend day food consumption questionnaire during the week preceding their yearly diabetes control consultation, when samples were collected for the assay of oxidative stress (OS) (blood levels of antioxidants, peroxides, malondialdehyde (MDA) and minerals). Blood samples were also collected from 25 age-and sex-matched healthy controls. Results: Diabetic patients had lower glutathione (5.8071.15 vs 6.7571.03 mmol/g Hb in the controls, P ¼ 0.002) and higher MDA (0.68770.212 vs 0.54570.101 mmol/l, P ¼ 0.002). Although the group average intakes were within the Belgian RDA, intakes of fat 435% energy, fibre o15 g/1000 kcal, fruit o2 portions and vitamin E o10 mg/day were seen in more than 20 patients. Blood antioxidants did not correlate with intakes of energy, fat, protein or fibres or of their respective antioxidant. Vitamins A and E correlated with serum lipids (r ¼ 0.58, P o0.0005 between serum a-tocopherol and cholesterol). Blood peroxide levels were only related to intakes of saturated fat and cholesterol (Po0.05). In diabetic subjects but not in controls (Po0.05) MDA was related to glutathione and uric acid. Conclusions: In diabetic patients, blood levels of antioxidants are not related to their dietary intakes but to serum lipids. Levels of oxidative damage products are only related to intakes of saturated fats and cholesterol and to levels of endogenous antioxidants.

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Section: Dietary Antioxidants In Diabetes Mellitusmentioning

confidence: 99%

Oxidative stress status in patients with diabetes mellitus: relationship to diet

et al. 2003

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“…Fibers also increase intestinal content, viscosity and volume thereby slowing processes of diffusion of micelles on the absorbent surface of enterocytes (Yonekura & Nagao, 2007;Eroglu & Harrison, 2013). Besides, Riedl et al (1999) confirmed that dietary fibers decrease carotenoids absorption in human. Differences in carotenoids bioavailability observed in our study could be explained by dietary fibers content of studied meals.…”

Section: Discussionmentioning

confidence: 66%

“…Nature and distribution of dietary fibers in the meals could also explain the difference in bioavailability. In fact, Riedl et al (1999) reported that effect of dietary fibers on carotenoids absorption varies according to the type of fiber.…”

Section: Discussionmentioning

confidence: 99%

Bioavailability of Palm Oil Carotenoids Consumed from Different Foods

Dongho

Ndomou

Ngono

et al. 2017

JFR

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Crude palm oil (CPO), an ingredient with a high content in provitamins A, is usually consumed associated with foods that could affect carotenoids metabolism. This work aimed to evaluate the influence of foodstuffs prepared with the incorporation of CPO on carotenoids absorption. Thus, we studied carotenoids bioavailability in Cameroonian local meals based on CPO and three different foodstuffs: maize (Zea mais), cassava (Manihot esculente) or black eyed peas (Vigna unguiculata). Modified 'yellow sauce' prepared mainly with CPO was used as control meal. Eleven healthy volunteers with age range between 20-30 year and similar body mass index were submitted to the study. A total of four interventions (i.e., meal ingestion) were performed every six days. After meal ingestion blood samples were collected at 0, 2, 4 and 6 h, and carotenoids content were analyzed by HPLC. Results showed that control meal had the highest carotenoids absorption (0.479±0.063 µg.h/ml.), followed by maize (0.329±0.115 µg.h/ml) and cassava (0.141±0.075 µg.h/ml) cakes. Food based on black eyed peas incorporated with CPO showed the smallest increase in blood carotenoids (0.053±0.062 µg.h/ml). Notably, CPO consumption leads to a short term significant increase of blood carotenoids (p<0.05) that declines over time. Our results suggest that the association of CPO with different foodstuffs significantly affects carotenoids bioavailability. This effect seems to be more important for leguminous, followed by tubers and cereals.

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“…However, there are insufficient data to firmly draw conclusions about this matter. Most likely, the effect of the fibre depends on the type of mineral or vitamin, the intestinal transit time and the degree of bacterial fibre degradation in the gut (64,80,81) . The combination therapy with soluble fibre and statins may also have some safety limits, while unfavourable reductions in HDL-cholesterol have been described and in one study reduced statin absorption from the gut was suggested after a high intake of soluble fibre (74) .…”

Section: Safety Aspects Of Combination Therapy With Soluble Dietary Fmentioning

confidence: 99%

Support of drug therapy using functional foods and dietary supplements: focus on statin therapy

et al. 2010

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Functional foods and dietary supplements might have a role in supporting drug therapy. These products may (1) have an additive effect to the effect that a drug has in reducing risk factors associated with certain conditions, (2) contribute to improve risk factors associated with the condition, other than the risk factor that the drug is dealing with, or (3) reduce drug-associated side effects, for example, by restoring depleted compounds or by reducing the necessary dose of the drug. Possible advantages compared with a multidrug therapy are lower drug costs, fewer side effects and increased adherence. In the present review we have focused on the support of statin therapy using functional foods or dietary supplements containing plant sterols and/or stanols, soluble dietary fibre, n-3 PUFA or coenzyme Q 10 . We conclude that there is substantial evidence that adding plant sterols and/or stanols to statin therapy further reduces total and LDL-cholesterol by roughly 6 and 10 %, respectively. Adding n-3 PUFA to statin therapy leads to a significant reduction in plasma TAG of at least 15 %. Data are insufficient and not conclusive to recommend the use of soluble fibre or coenzyme Q 10 in patients on statin therapy and more randomised controlled trials towards these combinations are warranted. Aside from the possible beneficial effects from functional foods or dietary supplements on drug therapy, it is important to examine possible (negative) effects from the combination in the long term, for example, in post-marketing surveillance studies. Moreover, it is important to monitor whether the functional foods and dietary supplements are taken in the recommended amounts to induce significant effects. Combination therapy: Dyslipidaemia: Statins: Functional foodsThe world market for functional foods (FF) and dietary supplements (DS) is expanding rapidly. In 2010 FF are expected to represent 5 % of the total global food market (1) and the market for DS is estimated at more than $60 billion worldwide (2) . In general, the target population of FF or DS is healthy individuals with slightly elevated risk factors or some physical discomfort. However, due to the fast growing market of FF or DS and the accompanying strong advertising and marketing, also patients on medication may be stimulated to use FF or DS. This may have several consequences for the quality of drug treatment as stated by de Jong et al. with the example of the combined intake of plant sterols and/or stanols and statins (3) . Whereas they addressed the additive effect of plant sterols and/or stanols on reducing LDL-cholesterol values in patients on statin treatment, their main focus was the possible negative aspects of the combination, such as unfavourable effects on patient adherence with drug treatment and increasing the potential for food-drug interactions.In the present review we will focus on the possible beneficial effects that FF or DS may have on drug therapy. Because of the large number of subjects treated suboptimally with statins (hydroxymethylglutaryl Co...

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Some Dietary Fibers Reduce the Absorption of Carotenoids in Women

Cited by 228 publications

References 42 publications

Oxidative stress status in patients with diabetes mellitus: relationship to diet

Oxidative stress status in patients with diabetes mellitus: relationship to diet

Bioavailability of Palm Oil Carotenoids Consumed from Different Foods

Support of drug therapy using functional foods and dietary supplements: focus on statin therapy

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