Some effects of cyproterone and cyproterone acetate on the reproductive physiology of the male rat

Abstract

Summary. Male rats were treated with 5 or 20 mg cyproterone acetate/kg/day or 20 mg cyproterone/rat/day for 1, 2, 3, 4 or 5 weeks. There was some reduction in fertility with both compounds, the maximum effect occurring after 5

Flutamide as an Androgen Antagonist on Epididymal Function in the Rat*

“…The results of the present study clearly establish that the secretory function of the epididymis, as revealed by the level of GPC is adversely affected by antiandrogens in castrated rats maintained on androgen replacement therapy.Though the two antiandrogens are equally effective in the classic antiandrogen test (Sufrin and Coffey -1976), flutamide fails to exert antiandorgenic effects on the epididymis (Dhar and Setty -1976) of uncastrated animals. Similar observations have been made by other investigators on the epididymis of intact rats treated with cyproterone acetate (Brooks et al -1974;Jones -1977;Back et al -1977). In contrast to their lack of effect on the epididymis of intact rats, both flutamide and cyproterone acetate are reported to be effective in reducing the weight and secretory function of SV and VP (Neri et al -1977;Dhar and Setty -1976;Sufrin and Coffey -1976;Brooks et al -1974;Jones -1977).…”

Effects of castration, 5 -dihydrotestosterone and cyproterone acetate on enzyme activity in the mouse epididymis

“…This understanding and a growing tendency to consider the epididymis as a target and model for studies on fertiUty control in the male indicate the importance of a detaüed investigation of aU androgen-dependent processes in this organ. To this end several morphological and biochemical parameters have been studied, for example, weight, epithelial cell height, glycolytic enzymes, pH, inorganic cations, carnitine, glycerylphosphoryl choline, sialic acid and proteinases (Prasad, Rajalakshmi & Reddy, 1972;Prasad et al, 1973;Brooks, 1976a, b;Nag, Sarkar & Ghosh, 1977;Jones, 1977;Back, Glover, Shenton & Boyd, 1977;Rastogi, 1979). The results suggested that there are structural and functional variations in the different regions of the epididymis in different species and in the epididymal response to androgen manipulations.…”

Effect of Chronic Use of Cyproterone Acetate on the Epididymis of Goat

“…The epididymis receives androgen from circulating blood and the testicular fluid that andrologia 14 (1982) Cyproterone acetate significantly reduced the number of sperms in all parts of the epididymis of both the treated groups. Androgen deficiency is known to cabse regression of the epididymal epithelium, reduction in tubule diameter, changes the composition of the luminal fluid (Jones -1974) and also a decline in the caudal sperm number (Jones and Glover -1973;Lubicz-Nawrocki and Glover -1973;Lubicz-Nawrocki -1974;Meistrich et al -1975;Back et al-1977). The reduced number could result from lower testicular sperm production, resorption of spermatozoa in the epididymis or an enhanced rate of sperm transport through the epididymis.…”