Some effects of dithizone on the canine prostate

Basic Studies on the Prostate of Rat Under Various Hormonal Environment

“…65Zn uptake of the intact rats and hormonal dependency(CPM/mg) Table 3. 65Zn uptake of the castrated rats and hormonal dependency (CPM/mg) As reported by Lo et al (1960) the change in Zn content of the prostate and the destruction of the glandular epithelium may be produced by chelate reagents. We have, therefore, investigated the influence of these reagents on 65Zn uptake of the prostate.…”

The Role of Diabetogenic Hyperinsulinism in the Pathogenesis of Prostatic Hyperplasia and Malignancy*

“…) Kadota (65b) successfully produced permanent diabetes mellitus in rabbits by administering dithizone, a chelating agent with an affinity for zinc. He suggested that such diabetes resulted from the chelation of zinc in the pancreatic beta cells. Lo and associates (65c) demonstrated that dithizone administered to dogs induces prompt cessation of prostatic fluid secretion, a decrease in the Zn 65 uptake by prostatic tissue, a marked fall in prostatic zinc concentration, and striking changes in the histologic appearance of the prostate. The rather selective necrosis within the lateral portion of the rat prostate contrasts with the slight changes in other lobes (59).…”