Some effects of mouse urine on neonatal growth and reproduction

Cowley, J.J.; Wise, D.R.

doi:10.1016/s0003-3472(72)80014-9

Cited by 85 publications

(38 citation statements)

References 12 publications

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“…Therefore, the possibility exists that GnRH could help coordinate reproductively related behavioral and motor functions with the secretion of gonadotropins. The presence of GnRH fibers within the olfactory system [this study, 16,28,33] is particu larly significant, because in rodents olfaction has been im plicated in the regulation of mating behaviors [23] as well as sexual maturation [2]. In recent studies of the vole [3], changes in the activity of the GnRH neuronal system were correlated with olfactory activity.…”

Section: Discussionmentioning

confidence: 99%

Gonadotropin-Releasing Hormone Neuronal System of the White-Footed Mouse, Peromyscus leucopus

Jd¹

1986

Neuroendocrinology

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The cytoarchitecture of the gonadotropin-releasing hormone (GnRH) neuronal system of the female white-footed mouse (Peromyscus leucopus) was characterized using immunocytochemical procedures on thick vibratome sections. Most of the labelled cell bodies are organized loosely into three groups associated with the periventricular region of the medial preoptic area, the diagonal band of Broca, and the olfactory peduncle. A small number of cells are scattered throughout the medial septum, retrochiasmatic area, and in the posterior hypothalamus, lateral from the median eminence (ME). Labelled fibers are distributed widely throughout the brain, with heavy concentrations within the ME and the organum vasculosum of the lamina terminalis (OVLT). A subchiasmatic pathway for GnRH fibers, which courses from the OVLT to the ME, was identified. Fiber plexuses are present in the olfactory bulbs, accessory olfactory bulbs, triangular nucleus of the septum, medial habenular nucleus, and the amygdala. The ependymal layer of the third ventricle that is associated with the ME and OVLT contains large numbers of GnRH fibers, some of which appear to extend into the ventricular lumen. The wide dispersion of the GnRH neuronal system throughout the brain of P. leucopus is evidence that, in addition to its role as a gonadotropin-releasing hormone, GnRH may have a neurophysiologic function in the central nervous system of this species.

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Section: Discussionmentioning

confidence: 99%

Gonadotropin-Releasing Hormone Neuronal System of the White-Footed Mouse, Peromyscus leucopus

Jd¹

1986

Neuroendocrinology

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“…The relationship between growth rate, gonadal activity and environmental stimuli (whether photoperiodic or pheromonal) seems not to be straight forward: an association between sexual maturation and growth rates has been reported for female mice and voles in response to various environmental factors (Cowley & Wise, 1972;Batzli, Getz & Hurley, 1977;Badloo & Clulow, 1981), while in other cases no such association has been found (Vandenbergh, Drickamer & Colby, 1972). It seems possible that gonadal hormones stimulate growth when their titre rises above a certain threshold, reached in these experiments in long photoperiods irrespective of the presence or absence of mature males.…”

Section: Introductionmentioning

confidence: 99%

Effect of male presence and of photoperiod on the sexual maturation of the field vole (Microtus agrestis)

Spears¹,

Clarke²

1986

Reproduction

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Summary. The effect of mature males on the sexual development of young female and male field voles, reared in either long (stimulating) or short (inhibiting) photoperiods, was examined. Females reared in the presence of a mature male had a more advanced state of sexual maturation (as indicated by uterine weight) than did females reared in isolation from males, in long and short photoperiods (P < 0\m=.\01). No interaction between photoperiod and male presence was found. Augmented uterine growth occurred not only when young females were separated from mature males by a wire mesh or solid metal screen but also when they were merely exposed to bedding previously used by mature males. Castrated males had no effect on the sexual development of females. The effect ofmature males on the sexual development of young males was less clear, although there was some indication that the presence of adult males inhibited their sexual development in long and short photoperiods. For males and females, growth rate was stimulated by long photoperiod, but no effect of male presence on growth rate was found.

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“…Details of the collecting, storing and application of the urine have been described elsewhere (Cowley and Wise, 1972). The urine from 5-6 mothers was mixed together and diluted with distilled water in a ratio of 5 parts of water to 1 part of urine and applied, with a fine artist's paintbrush, once daily to the dorsal nasal surface when the mice were 22-32 days of age.…”

Section: Introductionmentioning

confidence: 99%

Post-parturition and late lactation urine : long-term effects of exposure on mouse activity and sniffing behaviour

Cowley¹,

Pewtress²

1986

Reprod. Nutr. Dévelop.

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Summary. From the time of separation from their mothers infant mice were exposed for 10 consecutive days to urine from post-parturitional and late-lactational donor mice. They were then tested when adult on activity and sniffing behaviour.The sample of mice exposed to urine from late-lactational donors was associated with reduced activity when compared with mice exposed to post-parturitional urine and a water control sample. The long term effects of the urine on behaviour were also apparent in positional preferences in an open arena as judged by frequency of entry, and to a lesser extent, the time spent in the left and right hand segments. Mice exposed to late-lactational urine sniffed less than the other treatment samples though preferences for sniffing the urine that they had been exposed to in infancy were less marked. The urine did not accelerate puberty, but mice in the control sample had more vaginal dioestrous smears and fewer smears with a predominance of epithelial cells.Introduction.

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Some effects of mouse urine on neonatal growth and reproduction

Cited by 85 publications

References 12 publications

Gonadotropin-Releasing Hormone Neuronal System of the White-Footed Mouse, <i>Peromyscus leucopu</i><i>s</i>

Gonadotropin-Releasing Hormone Neuronal System of the White-Footed Mouse, <i>Peromyscus leucopu</i><i>s</i>

Effect of male presence and of photoperiod on the sexual maturation of the field vole (Microtus agrestis)

Post-parturition and late lactation urine : long-term effects of exposure on mouse activity and sniffing behaviour

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