Summary
1. Two hundred and eighty‐eight radiant energy burns were produced on anesthetized pigs and were studied at biopsy at 4, 24 and 48 hr. There is progressive destruction of epithelial cells in hair follicles and “sweat” glands during this interval.
2. In radiant energy burns of the ears of anesthetized rabbits, peripheral nerve fibers are progressively destroyed for two days after injury.
3. To compare the effects of superimposing two burns, 588 single or double exposures to radiant energy were made on anesthetized pigs. Intervals between double exposure were one min, one hr, five hr or six hr. The results show that some tissue, which will remain viable if left alone, will be destroyed by a second exposure, which would not, by itself, have caused detectable injury to that tissue.
4. Many varieties of systemic fluid therapy can insure the early survival of severely burned patients. It is proposed that we would have good reason to prefer one over the others, if it could be shown to halt or decrease progressive tissue destruction during the early hours or days following a burn.