The aim of this paper is to identify the main drivers of highly skilled migration between regions. We argue that the spatial mobility of individuals should not be considered in terms of one-off displacements, but rather as a sequence of migration decisions within a certain time period. The important context of the research is provided by the economic transformation of Poland, accompanied by the growing demand for education, and the lack of well-established patterns of graduate mobility. By applying multinomial logit modelling on a unique database of Polish graduates, we find that all the tested migration strategies can be explained in terms of structural factors, human capital characteristics or aspirations/capabilities related variables.