Some Extrapyramidal Motor Signs in Cases of Undifferentiated Amentia

Abstract

A group of 50 mentally handicapped patients who were without gross motor deficit and had never been on anti-psychotic drugs were examined for signs of Parkinsonism and compared with a matched control group of non-handicapped people who were also examined. There was a very significant increase in masking, positive glabella tap, absence of arm swing, rigidity and hypokinesis.

Levodopa-Responsive Parkinsonism in a Patient with Down’s Syndrome

“…Extrapyramidal signs in patients with DS are not very common although bradykinesia and a positive glabellar sign have been described [4], These reports describe only isolated extrapyramidal findings but do not indicate the presence of a parkinsonian syndrome. The occurrence in our patient of a distinct parkinsonian presentation (rest ing tremor, cogwheel rigidity, festinating gait, impaired postural reflexes) has not been previously reported.…”