Some findings in patients with uraemic stomatitis

Hovinga, J; Roodvoets, A. P.; Gaillard, J

doi:10.1016/s0301-0503(75)80029-4

Cited by 18 publications

(9 citation statements)

References 2 publications

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“…An acute form of necrotic pseudomembranous gingivostomatitis can occasionally be observed in patients who rapidly develop high blood urea nitrogen levels. 8,9 The possible causes include the following: tissue reactions to toxins or to uratemic catabolites; the hydrolyzing action of the oral bacterial flora on the urea that results in the formation of irritant ammonium compounds; and hemorrhagic diathesis, which is common manifestation of uratemic syndromes. 10 A small local hemorrhage in the oral cavity can cause tissue dystrophy, which is a condition that is predisposing to the development of bacterial infection.…”

Section: Uratemic Stomatitismentioning

confidence: 99%

Oral manifestations in chronic uremia patients

et al. 2015

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The incidence of chronic renal failure (CRF) is approximately 200 cases per million people in different Western countries. Recent data indicate that the incidences of these pathologies are increasing. Ninety percent of patients with CRF report oral signs and symptoms that affect both the bone and soft tissues. A broad range of lesions may be observed in chronic uratemia patients, including the following: gingival hyperplasia, enamel hypoplasia, petechiae, gingival bleeding, and others lesions. These patients require various types of treatment ranging from dietary and lifestyle changes to dialysis and kidney transplantation. CRF often leads to multiple oral manifestations that are difficult for dentists to manage. The present study examined the characteristics of this disease, the existing therapeutic options and the relevant considerations for dental professionals.

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Section: Uratemic Stomatitismentioning

confidence: 99%

Oral manifestations in chronic uremia patients

et al. 2015

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“…The first two forms may occur as painful anterior mucosal lesions on the ventral tongue that usually heal spontaneously, after treatment of uremia (43). The hemorrhagic and hyperkeratotic forms may occur because of bleeding diathesis and long standing uremia, respectively (42).…”

Section: Common Orofacial Problems In Ckd Patientsmentioning

confidence: 99%

Systemic Consequences of Poor Oral Health in Chronic Kidney Disease Patients

Akar

Carrero

et al. 2011

Clinical Journal of the American Society of Nephrology

168

136

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SummaryChanges in the oral cavity, such as periodontitis and other manifestations of poor oral health, are common in patients with chronic kidney disease (CKD) and may contribute to increased morbidity and mortality because of systemic consequences such as inflammation, infections, protein-energy wasting, and atherosclerotic complications. Poor oral health in CKD patients may thus represent an important, but often overlooked, problem. Several studies show that uremic patients have higher rates of decayed, missing, and filled teeth, loss of attachment, and periapical and mucosal lesions than the general population. The consequences of poor oral health may be more severe in CKD patients because of advanced age, common comorbidities such as diabetes, concurrent medications, and a state of immune dysfunction that may increase the risk for systemic consequences of periodontitis and other oral and dental pathologic conditions. Poor dentition and other signs of poor oral health should be an alarm clock also at early stages of CKD. However, it remains to be determined whether more successful management of poor oral health and periodontitis will reduce the risk of inflammation, infection, protein-energy wasting, and atherosclerotic complications in CKD patients. This review explores etiological factors and potential systemic consequences of poor oral health in CKD patients as well as possible preventive and therapeutic strategies.

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“…These patients have elevated concentrations of nitrogenous wastes in the blood including concentrations of urea in the millimolar range. [37][38][39] Urea, in these concentrations, may be capable of producing a mild chemical denaturation of proteins. ULVWF multimeric strings secreted from the stimulated endothelial cells of uremic patients may be subjected to the chemical denaturation effects of elevated urea concentrations in addition to shear stress and the tensile stress of adherent platelets.…”

Section: Medical Significancementioning

confidence: 99%