Some Further Studies on Tuberculostatic Compounds

Bavin, E. M.; Drain, D.; Seiler, M.; Seymour, D. E.

doi:10.1111/j.2042-7158.1952.tb13218.x

Cited by 53 publications

(13 citation statements)

References 3 publications

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“…Buu-Hoi et al synthesized some hydrazide-hydrazones that were reported to have lower toxicity than hydrazides because of the blockage of -NH2 group. These findings further support the growing importance of the synthesis of hydrazidehydrazones compound 9,10 . Iron is necessary for the biochemical reactions of living organisms.…”

Section: Introductionsupporting

confidence: 76%

Biological Activities of Hydrazone Derivatives in the New Millennium

Negi¹

2013

Int J Pharmceut Chem

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ABSTRACT:Hydrazones are present in many of the bioactive heterocyclic compounds that are of wide interest because of their diverse biological and clinical applications. This created interest in researchers who have synthesized variety of hydrazone derivatives and screened them for their various biological activities viz. anticonvulsant, antidepressant, analgesic, anti-inflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, anticancer, vasodialator, antiviral, antischistosomiasis, anti-HIV, anthelmintic, antidiabetic and trypanocidal activities. Hydrazones possessing an azometine -NHN=CH-proton constitute an important class of compounds as target structures and evaluated their biological activities. These observations have been guiding for the development of new hydrazones that possess varied biological activities.

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Section: Introductionsupporting

confidence: 76%

Biological Activities of Hydrazone Derivatives in the New Millennium

Negi¹

2013

Int J Pharmceut Chem

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“…These compounds were reported to have inhibitory activity in mice infected with various strains of M. tuberculosis [5]. They also showed less toxicity in these mice than INH [5,6] Buu-Hoi et al synthesized some hydrazide-hydrazones that were reported to have lower toxicity than hydrazides because of the blockage of -NH 2 group. These findings further support the growing importance of the synthesis of hydrazide-hydrazones compound [7].…”

Section: Nifuroxazide Isoniazidmentioning

confidence: 99%

“…Meyer and Mally prepared new hydrazones by reacting isoniazid (INH) with benzaldehyde, o-chlorobenzaldehyde and vanilin [5]. Shchukina et al prepared INH hydrazide-hydrazones 1 by reacting INH with various aldehydes and ketones; the compounds were reported to have activity in mice which had been infected with various strains of M. tuberculosis, and also indicated lower toxicity than INH [5,6]. [40].…”

Section: Antimycobacterial Activitymentioning

confidence: 99%

Biological Activities of Hydrazone Derivatives

2007

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There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, antiinflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and antischistosomiasis activities. Hydrazones possessing an azometine -NHN=CH-proton constitute an important class of compounds for new drug development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations have been guiding for the development of new hydrazones that possess varied biological activities.

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“…Meyer and Mally prepared new hydrazones by reacting isoniazid (INH) with benzaldehyde, o-chlorobenzaldehyde and vanilin 5 . Shchukina et al prepared INH hydrazidehydrazones 1 by reacting INH with various aldehydes and ketones; the compounds were reported to have activity in mice which had been infected with various strains of M. tuberculosis, and also indicated lower toxicity than INH 5,6 . antitumoral activity.…”

Section: Analgesic Anti-inflammatory and Antiplatelet Activitymentioning

confidence: 99%

Untitled

2011

IJPSR

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There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, antiinflammatory, anti platelet, anti malarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and antis chistosomiasis activities. Hydrazones possessing an azometine -NHN=CH-proton constitute an important class of compounds for new drug development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations have been guiding for the development of new hydrazones that possess varied biological activities.

show abstract

Some Further Studies on Tuberculostatic Compounds

Cited by 53 publications

References 3 publications

Biological Activities of Hydrazone Derivatives in the New Millennium

Biological Activities of Hydrazone Derivatives in the New Millennium

Biological Activities of Hydrazone Derivatives

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