Some Haematological Parameters of Symptomatic and Asymptomatic Hepatitis B Positive Patients Attending a Nigerian Tertiary Hospital

Ajugwo, Anslem O.; Ukaji, D.C.; Erhabor, Tosan; Adias, Teddy Charles

doi:10.9734/bjmmr/2015/15491

Cited by 7 publications

(9 citation statements)

References 6 publications

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“…Hematological parameters and absolute CD4 Cell count analysis showed that blood samples of some blood donors infected with occult and overt HBV infection have low values of some hematological indices. Findings from our hematological and CD4 + T cell analysis corroborates with the study of Ajugwo et al [14] in Nigeria, which also found no significant difference in hematological indices (HCT, HGB, WBC Total and ESR) between symptomatic and asymptomatic patients infected with HBV. They concluded that patients with HBV infection have the tendency to develop anaemia if not adequately and properly managed.…”

Section: Occultsupporting

confidence: 92%

“…Hematological parameters such as red blood cells (RBC), white blood cells (WBC), and platelets are blood cells in the complete blood count that have unique functions [13]. Studies have shown that these cells function and values are altered in disease conditions such as viral hepatitis [12,14]. Alanine Aminotransferase (ALT) is one of the enzymes released into plasma following cell death or injury.…”

Section: Introductionmentioning

confidence: 99%

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Hepatitis B Virus Infection and Biomarkers Correlates of Liver Injury among Healthy Blood Donors in Nigeria

Osuji

Agbakoba

Ifeanyichukwu

et al. 2020

JAMMR

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Objectives: Destruction of blood cells and damage to hepatocytes are the hallmark of hepatitis B viral infection. This cross-sectional study was undertaken to evaluate some hematological parameters and biomarkers of liver injury in healthy blood donors infected with the occult and overt hepatitis B attending the University of Abuja Teaching Hospital (UATH) and Nnamdi Azikiwe University Teaching Hospital (NAUTH) Nnewi, Nigeria. JAMMR, 32(2): 69-78, 2020; Article no.JAMMR.54812 70 Materials and Methods: A total of 20 overt and 14 occult hepatitis B virus-infected blood donors were confirmed and enrolled using Roche ® COBAS q-PCR from 212 consented pooled subjects. Hematological parameters and absolute CD4 + T-cell count were determined using the Sysmex hematology analyzer and Partec cyflow counter, respectively. Determination of serum Alanine Aminotransferase (ALT) and Alpha Feto-protein (AFP) levels were done spectrophotometrically and ELISA, respectively. Results: The mean red blood cells, hematocrit, hemoglobin, white blood cells, CD4 and platelet count in the overt group were not statistically significantly different from the occult group p>0.05. However, of the 34 infected subjects, 7 (20.6%), 6 (17.7%), 2 (5.9%), 13 (38.2%), 2 (5.9%) and 4 (11.8%) had abnormally low blood values for red blood cells, white blood cells, hematocrit, hemoglobin, CD4 and platelets respectively. The mean ALT and ALP values from the occult and overt groups were not also significantly different (p>0.05). Conclusion: This study found a decrease in the values of some blood cells. However, no significant changes in the liver enzymes were found. These infected individuals should be managed to prevent transmission of HBV infection to other people and subsequent destruction of blood cells and damage to liver cells. Future studies could focus on patients with chronic liver diseases/Hepatocellular carcinoma caused by HBV to determine the effects on the liver biomarkers and hematological parameters. Original Research Article

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Section: Occultsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Hepatitis B Virus Infection and Biomarkers Correlates of Liver Injury among Healthy Blood Donors in Nigeria

Osuji

Agbakoba

Ifeanyichukwu

et al. 2020

JAMMR

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“…Previous studies conducted in Western countries have shown that chronic liver disease especially due to HBV was the fifth leading cause of death among HIV infected pregnant women [7]. In another study, clinical assessment of hepatitis B virus positive patients showed that majority of them (68%) had no symptom (asymptomatic patients) while few of them (32%) had symptoms (symptomatic patients) such as abdominal pain, jaundice, pale dark urine, nausea, loss of appetite and body ache [8].…”

Section: Introductionmentioning

confidence: 95%

Co-infection of HIV, HBsAg and HCV Among Pregnant Women of African Descent

Ajugwo¹,

Mounbegna²,

Dunga³

et al. 2018

Int J Immunol Immunobiol

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Human Immunodeficiency Virus (HIV), Hepatitis C virus and Hepatitis B virus (HBV) are blood borne pathogens that can be transmitted through sexual contact, vertical transmission, and could pose great danger in healthcare delivery. Prevalence of co-infection of HIV, HBsAg and HCV was determined in pregnant women of African descent. One hundred (100) pregnant women of African descent were used for the study having obtained their consent and approval by the Research and Ethics committee. The screening and confirmatory tests were done using double check gold and Immunocomb II respectively while HBsAg and HCV were determined with one step test strip. Out of the one hundred (100) subjects studied, the prevalence rate was noted as 15%, 6% and 2% for HIV, HBsAg and HCV respectively. Co-infection of HIV and HBsAg was more prevalent, followed by co-infection of HIV and HCV and lastly co-infection of HBsAg and HCV. The age group of 25-29 years tested positive to HIV, HBsAg and HCV. All other age groups tested positive to HIV and either HBsAg or HCV while age group of 20-24 years tested positive to only HIV and negative to both HBsAg and HCV. Though these rates might be lower compared to previous studies, counseling and enlightenment campaigns should be sustained especially on the mode of transmission, prevention and management of these diseases. Government should ensure that compulsory screening for pregnant women is available and affordable at all levels.

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“…HBV is known to affect mainly the liver but the inflammatory and immune response in HBV infected patients can affect the clinical, serological and hematological outcome of the patient as the severity of the viral disease depends on the immune system's ability to attack infected hepatocytes [32]. Our study looked at possible changes in some hematological parameters (HB, RBC, WBC, PLT, HCT, Neutrophil and lymphocyte) that may have been brought about by HBV infection.…”

Section: Discussionmentioning

confidence: 99%

Identifying Possible Hepatic Fibrosis of Hepatitis B Origin Using Non-invasive Markers: A Case-control Study in the South West Region of Cameroon

Tufon

Meriki²,

Kwenti³

et al. 2019

MRJI

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Aim: HBV infection is known to cause liver fibrosis as well as some extrahepatic manifestations. We aimed at assessing hematological changes and identifying possible hepatic fibrosis of Hepatitis B origin using non-invasive markers (NIMs). Study Design: A hospital-based Case-control study Place and Duration of Study: Conducted at the Buea Regional Hospital, South West Region of Cameroon from February 2016 to December 2017 Methods: We enrolled HBV infected treatment naïve patients and “healthy” controls. All participants were subjected to alanine aminotransferase (ALT) and aspartate aminotransferase (AST) measurement, Full blood count (FBC), HBsAg, anti-HBc, HIV and HCV tests. Aspartate-platelet ratio index (APRI), fibrosis based on 4 factors (FIB-4), age-platelet index (API) and AST/ALT ratio (AAR) were generated from the test results. A questionnaire was administered to collect demographic data, alcohol consumption and history of liver/kidney disease or metabolic syndrome. Results: A total of 202 cases and 202 controls were enrolled. Hematocrit (HCT) was significantly higher (p<0.001) in cases than controls. The controls had significantly higher mean values for platelet (p=0.005), neutrophil (p=0.032) and number of individuals with AST/ALT ratio (AAR) ≥1. Liver fibrosis was significantly associated with cases than controls based on APRI (OR:6.06, CI:3.59-10.24), FIB-4 (OR:5.35, CI:2.75-10.39) and API (OR:8.02, CI:1.81-35.55). Among the HBV infected cases, 69 (34.2%), 36(17.8%) and 8(4.0%) had results indicative of fibrosis from at least 2, at least 3 and all 4 NIMs respectively. AAR detected possible fibrosis in 136 HBV infected cases of which up to 77 (56.6%) were not detected as fibrosis by the other NIMs. Conclusion: HBV infection affects neutrophil percentage, HCT, PLT, APRI, FIB-4 and API in our study population. AAR did not prove to be a reliable NIM. Using at least 3 NIMs for HBV infected patients can significantly scale up their reliability for determining liver fibrosis in clinical practice.

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Some Haematological Parameters of Symptomatic and Asymptomatic Hepatitis B Positive Patients Attending a Nigerian Tertiary Hospital

Cited by 7 publications

References 6 publications

Hepatitis B Virus Infection and Biomarkers Correlates of Liver Injury among Healthy Blood Donors in Nigeria

Hepatitis B Virus Infection and Biomarkers Correlates of Liver Injury among Healthy Blood Donors in Nigeria

Co-infection of HIV, HBsAg and HCV Among Pregnant Women of African Descent

Identifying Possible Hepatic Fibrosis of Hepatitis B Origin Using Non-invasive Markers: A Case-control Study in the South West Region of Cameroon

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