Some haematological profiles of children with malaria parasitaemia in Port Harcourt, Nigeria

Wokem, GN; Okafor, RA; Nwachukwu, BC

doi:10.4314/njpar.v29i2.37911

Cited by 4 publications

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“…Although other parameters like lymphocytes and WBC were lower while neutrophils were slightly higher when compared to control but they were not statistically significant (P>0.05). These results are in agreement with the findings of Wokem et al [24,3] who made similar observations.…”

Section: Discussionsupporting

confidence: 94%

Malaria Status in Relation to Risk Factors among Attendees of Two Health Facilities in Port Harcourt, Rivers State, Nigeria

Wokem¹,

Erasmus²,

Wokem³

2020

JAMMR

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A cross sectional study was conducted among subjects from two health facilities in Port Harcourt to assess malaria status and its health determinants. Seven hundred subjects of different ages and both sexes were investigated after ethical approval was obtained from Rivers State Ministry of Health, Port Harcourt, Nigeria. Written consent of the subjects was obtained before questionnaire administration to obtain the demographic data. The uninfected subjects were used as control. Four (4) mls of blood was taken from each subject by vein-puncture into separate EDTA bottles for haematological profile tests and malaria parasite identification using standard haematological and parasitological techniques. The overall prevalence of malaria was 27%. The males had slightly higher prevalence (27.8%) than the females (26.5%), though the difference was not statistically significant (P> 0.05). The highest prevalence occurred among females (48.4%) of age group <1-10yrs and followed by males (40.7%) of same age group, and followed by males of 11-20 yrs with 36.4%. From risk groups related prevalence the School children (45%) were the most infected, followed by Blood donors (35.7%) and pregnant women (26.5%). Only the Packed Cell Volume was significantly affected adversely by malaria (P<0.0001), of all the haematological Parameters tested.

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Section: Discussionsupporting

confidence: 94%

Malaria Status in Relation to Risk Factors among Attendees of Two Health Facilities in Port Harcourt, Rivers State, Nigeria

Wokem¹,

Erasmus²,

Wokem³

2020

JAMMR

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“…Based on the STROBE criteria, two-thirds of studies (75%) were of moderate quality [22,24,[26][27][28][29][30][31][33][34][35][36][38][39][40][41]43,[45][46][47][48]50,[52][53][54][55]. Meanwhile, eight studies were of high quality (22.2%) [23,25,31,37,42,44,51,56], and one was of low quality (2.78%) [49] (Table S3).…”

Section: Reporting Quality Of the Included Studies And Qualitative Sy...mentioning

confidence: 99%

“…The remaining seven studies reported a higher proportion of malaria in Rh+ individuals than in Rh− individuals, though no statistical significance or statistical analysis has been performed [21,32,38,43,50,53,54]. Sixteen studies (44.4%) showed a lower proportion of malaria in Rh+ individuals than in Rh− individuals [23,24,26,[29][30][31]34,37,39,40,44,45,47,48,52,55]. Among these studies, a significantly lower proportion of malaria among Rh+ individuals was reported by two studies [39,44].…”

Section: Reporting Quality Of the Included Studies And Qualitative Sy...mentioning

confidence: 99%

“…Eleven studies reported a lower proportion of malaria among Rh+ individuals than in Rh− individuals, however, no statistical analysis has been performed [23,24,26,[29][30][31]34,40,47,52,55]. The other seven studies reported the association between the Rh blood group and malaria infection [22,28,49], parasite density [33,36], or malaria severity [35,51].…”

Section: Reporting Quality Of the Included Studies And Qualitative Sy...mentioning

confidence: 99%

“…Thirty-two studies with a study population of 1,007,763 reported the quantitative number of participants with malaria infection and Rh blood groups, which were included in the meta-analysis of the pooled log OR [21,[23][24][25][26][27][29][30][31][32][33][34][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56]. Results of individual studies showed increased odds of having malaria among Rh+ individuals in six studies [25,27,32,42,51,53].…”

Section: Association Between Rhesus Blood Groups and Malariamentioning

confidence: 99%

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Association between Rhesus Blood Groups and Malaria Infection: A Systematic Review and Meta-Analysis

et al. 2023

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In the literature, there was inconsistency in the risk of malaria between individuals with Rhesus blood group positive (Rh+) and negative (Rh−). The systematic review aimed to investigate the risk of malaria among participants with different Rh blood types. All observational studies that reported the occurrence of Plasmodium infection and investigation of the Rh blood group were searched in five databases (Scopus, EMBASE, MEDLINE, PubMed, and Ovid). Strengthening the Reporting of Observational Studies in Epidemiology was used to assess the reporting quality in the included studies. A random-effects model was used to calculate the pooled log odds ratio and 95% confidence intervals (CIs). Database searches yielded a total of 879 articles, of which 36 were eligible for inclusion in the systematic review. The majority of the included studies (44.4%) revealed that Rh+ individuals had a lower proportion of malaria than Rh− individuals; however, the remaining studies revealed a higher or no difference in the proportion of malaria between Rh+ and Rh− individuals. Overall, with moderate heterogeneity, the pooled results showed no difference in malaria risk between patients with Rh+ and Rh− (p = 0.85, pooled log odds-ratio: 0.02, 95% CI: −0.20–0.25, I2: 65.1%, 32 studies). The current study found no link between the Rh blood group and malaria, even though there was a moderate amount of heterogeneity. Further studies using prospective designs and a definitive method for Plasmodium identification are needed to investigate the risk of Plasmodium infection in Rh+ individuals and increase the reliability and quality of these studies.

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Case Study for Hepatic Involvement of Children with Malaria

Ikpeama,

Okeke,

Okolonkwo

et al. 2023

IJPR

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Background: Malaria has a significant impact on public health and economic development in affected regions such as Sub-Saharan Africa. It is a global problem affecting people every year leading to a substantial number of deaths especially among children under the age of 5. Aim: A cross sectional study of Evaluation of hepatic involvement of children with malaria among the middle age children (6-10years) attending some hospitals and schools in South South region of Nigeria was conducted. Methodology: Following ethical approval from the institutions as well as concrete consent from the children’s families, 418 randomly selected children aged 6 to 10 years participated in the study. Out of this number, 298 children had malaria and 120 children who had no malaria were taken to be the control. Blood was collected through the vein using syringe into ethylene diaminetetracetic acid and lithium bottles. Giemsa stain was used to stain the blood films. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyltransferase (GGT), albumin and total protein were analysed with the conventional biochemical methods. Results: Analysis of the data obtained showed that Aspartate aminotransferase (AST) 18.12±0.47, alanine aminotransferase (ALT) 8.56±0.12, alkaline phosphatase (ALP) 69.55± 0.87 and gamma glutamyltransferase (GGT) 21.41±0.29 values increased (P<0.05) in malaria subjects significantly when compared with the control 5.58±18, 4.62±0.17, 16.58±0.57 and 16.64±0.29 respectively. The study equally revealed that the test group showed significant (P<0.5) decrease of albumin 30.40±0.37 values when compared with the control group54.87±0.90. Conclusion: The changes in these liver parameters go on to suggest that plasmodiasis might have adverse effect on the hepatic functionality (integrity) as well as the function. Therefore, this should not be neglected as such neglect might result to mortality.

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Some haematological profiles of children with malaria parasitaemia in Port Harcourt, Nigeria

Cited by 4 publications

References 0 publications

Malaria Status in Relation to Risk Factors among Attendees of Two Health Facilities in Port Harcourt, Rivers State, Nigeria

Malaria Status in Relation to Risk Factors among Attendees of Two Health Facilities in Port Harcourt, Rivers State, Nigeria

Association between Rhesus Blood Groups and Malaria Infection: A Systematic Review and Meta-Analysis

Case Study for Hepatic Involvement of Children with Malaria

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