Some in vivo effects in the rat induced by chlorprothixene and potassium oxonate

Stavrić, B.; Clayman, S.; Gadd, R. E. A.; Hebert, Daniel N.

doi:10.1016/s0031-6989(75)80015-4

Cited by 53 publications

(44 citation statements)

References 11 publications

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“…The hyperuricaemic mice were induced by an intraperitoneal injection with uricase inhibitor potassium oxonate (Stavric et al 1975;Hall et al 1990). Male mice were divided into the normal control group, the untreated hyperuricaemic control group and treated hyperuricaemic groups.…”

Section: Preparation Of Compounds Testedmentioning

confidence: 99%

Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity

Niu

Liu

et al. 2016

Pharmaceutical Biology

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Context Mangiferin has been reported to possess a potential hypouricaemic effect. However, the pharmacokinetic studies in rats showed that its oral bioavailability was only 1.2%, suggesting that mangiferin metabolites might exert the action. Objective The hypouricaemic effect and the xanthine oxidase inhibition of mangiferin and norathyriol, a mangiferin metabolite, were investigated. Inhibition of norathyriol analogues (compounds 3-9) toward xanthine oxidase was also evaluated. Materials and methods For a dose-dependent study, mangiferin (1.5-6.0 mg/kg) and norathyriol (0.92-3.7 mg/kg) were administered intragastrically to mice twice daily for five times. For a timecourse study, mice received mangiferin and norathyriol both at a single dose of 7.1 mmol/kg. In vitro, inhibition of test compounds (2.4-2.4 mM) against xanthine oxidase activity was evaluated by the spectrophotometrical method. The inhibition type was identified from Lineweaver-Burk plots. Results Norathyriol (0.92, 1.85 and 3.7 mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively. The action was more potent than that of mangiferin at the low dose, but was equivalent at the higher doses. Additionally, the hypouricaemic action of them exhibited a time dependence. In vitro, norathyriol markedly inhibited the xanthine oxidase activities, with the IC 50 value of 44.6 mM, but mangiferin did not. The kinetic studies showed that norathyriol was an uncompetitive inhibitor by Lineweaver-Burk plots. The structure-activity relationships exhibited that three hydroxyl groups in norathyriol at the C-1, C-3 and C-6 positions were essential for maintaining xanthine oxidase inhibition. Discussion and conclusion Norathyriol was responsible for the hypouricaemic effect of mangiferin via inhibiting xanthine oxidase activity. ARTICLE HISTORY

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Section: Preparation Of Compounds Testedmentioning

confidence: 99%

Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity

Niu

Liu

et al. 2016

Pharmaceutical Biology

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“…The uricase inhibitor potassium oxonate was used to induce hyperuricemia in Balb/c mice as previously described (Stavric et al, 1975;Zhu et al, 2004;Zhao et al, 2006). Briefly, mice were injected intraperitoneally with potassium oxonate at a dose of 250 mg/kg.…”

Section: Hyperuricemia Model In Micementioning

confidence: 99%

“…Potassium oxonate, a selective competitive uricase inhibitor, blocks the effect of hepatic uricase and produces hyperuricemia in rodents (Stavric et al, 1975;Zhao et al, 2006;Wang et al, 2008). The Balb/c-potassium oxonate mouse has been widely applied to study the pathophysiology of hyperuricemia and therapeutic modulators of uric acid formation.…”

Section: Dose-dependent Lowering Of Hyperuricemia By H Reticulatus Amentioning

confidence: 99%

Antioxidant, antihyperuricemic and xanthine oxidase inhibitory activities ofHyoscyamus reticulatus

Mohammad¹,

Almasri²,

Tawaha³

et al. 2010

Pharmaceutical Biology

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“…Oxonate, a selectively competitive uricase inhibitor, blocks the effect of hepatic uricase, and produces hyperuricemia in rodents (Stavric et al, 1975;Hall et al, 1990). Oxonate-treated mice can serve as a useful animal model not only to evaluate drugs that affect serum urates but also to evaluate possible therapeutic agents in certain disorders associated with uric acid.…”

Section: Discussionmentioning

confidence: 99%

Reducing effect of mangiferin on serum uric acid levels in mice

Niu

Gao

et al. 2012

Pharmaceutical Biology

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Some in vivo effects in the rat induced by chlorprothixene and potassium oxonate

Cited by 53 publications

References 11 publications

Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity

Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity

Antioxidant, antihyperuricemic and xanthine oxidase inhibitory activities ofHyoscyamus reticulatus

Reducing effect of mangiferin on serum uric acid levels in mice

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