Some Inflammatory and Endothelial Dysfunction Biomarker levels in Obese Pre-pubertal Children

Na, Elnashar.; Aa, Elhosary; Ma, Elnashar.; Ha, Mohamed

doi:10.9790/264x-03027177

Cited by 2 publications

(1 citation statement)

References 36 publications

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“…According to Zoair et al, 7 obese children had significantly higher total TG and lower HDL compare with healthy children. However, Elnashar et al 10 found that all types of lipids were significantly associated with obesity.…”

Section: Discussionmentioning

confidence: 98%

Inflammatory markers and lipid profiles in obese children

Juliaty¹,

Kurniasih²

2021

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Background Over 340 million children and adolescents aged 5-19 were overweight or obese in the year 2016. Individuals with obesity are at risk for metabolic disorders and lipid abnormalities. Adipose tissue is a major source of pro-inflammatory cytokines. Objective To evaluate possible correlations between inflammatory markers IL-6, TNFa, and hs-CRP with lipid profiles between obese and non obese children. Methods Eighty children, aged 13 to 15 years, were enrolled in this study (40 normoweight and 40 obese). All participants’s ( obese and normoweight children) total plasma cholesterol, HDL cholesterol, triglycerides, as well as circulating levels of inflammatory factors, such as TNF-α, IL-6, and high sensitivity-C-reactive protein (hs-CRP) level were measured. Results Obese children had significantly higher triglycerides (TG) and cholesterol, as well as lower HDL than normoweight subjects. Mean LDL levels were not significantly different between groups. The IL-6, TNFa, hs-CRP levels were significantly positively correlated with waist circumference. Analysis of the 4 blood lipid parameters and 3 inflammatory markers revealed significant positive correlations of triglycerides to TNFa and hs-CRP. In addition, HDL had significant negative correlations to both TNFa and hs-CRP. No correlations were found between IL-6 and the 4 lipid parameters, nor between TNFa or hs-CRP to LDL and cholesterol. Multivariate regression analysis revealed a significant association between weight-height ratio with hs-CRP (R2 0.118; 95%CI 1.65 to 191; P=0.046). Obesity is associated with adverse lipid and inflammations markers in children. Conclusion Obesity was associated with higher TG, cholesterol, TNF, and hs-CRP levels, as well as lower HDL.

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Section: Discussionmentioning

confidence: 98%

Inflammatory markers and lipid profiles in obese children

Juliaty¹,

Kurniasih²

2021

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Predictive Markers of Early Cardiovascular Impairment and Insulin Resistance in Obese Pediatric Patients

et al. 2021

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Background: The increased prevalence of obesity among children determined the rising number of its comorbidities in children and adults, too. This study aimed to evaluate certain markers of inflammation and insulin resistance in obese pediatric patients, identifying those who are more likely to develop further complications. Methods: We included 115 obese pediatric patients: 85 overweight and obese patients in the study group and 30 normal-weight patients in the control group. We calculated the body mass index (BMI) and we evaluated markers (biological, inflammatory) and the hormones profile. Results: Low-threshold inflammation was assessed by measuring interleukin 6 IL-6 and Intercellular Adhesion Molecules (ICAM). The analysis showed that IL-6 is significantly correlated with glucose (p = 0.001) and BMI value (p = 0.031). ICAM correlates significantly with triglycerides (p = 0.001), glucose (p = 0.044) and BMI percentile (p = 0.037). For pediatric obese patients, endotoxemia has been significantly correlated only with BMI percentile (p = 0.001). Plasma cortisol did not show significant correlations with total cholesterol, triglycerides, glucose or BMI percentile. The results indicated a significant predictive power of BMI percentile on inflammatory markers: IL-6 (AUC = 0.803, p < 0.001), ICAM (AUC = 0.806, p < 0.001) and endotoxemia (AUC = 0.762, p = 0.019). Additionally, BMI percentile has a significant predictive power for metabolic markers of insulin resistance (insulin value: AUC = 0.72, p < 0.001 and HOMA index: AUC = 0.68, p = 0.003). Conclusions: The study highlighted the importance of early markers of cardiovascular risk in obese pediatric patients represented by IL-6, ICAM, endotoxemia and their correlation with metabolic markers of insulin resistance represented by insulinemia, HOMA index and plasma cortisol. It can clearly be considered that the BMI percentile has significant predictive power for metabolic markers of insulin resistance.

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Some Inflammatory and Endothelial Dysfunction Biomarker levels in Obese Pre-pubertal Children

Cited by 2 publications

References 36 publications

Inflammatory markers and lipid profiles in obese children

Inflammatory markers and lipid profiles in obese children

Predictive Markers of Early Cardiovascular Impairment and Insulin Resistance in Obese Pediatric Patients

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