2016
DOI: 10.1007/s10565-016-9333-1
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Some leopards can change their spots: potential repositioning of stem cell reprogramming compounds as anti-cancer agents

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Cited by 16 publications
(12 citation statements)
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“…This is particularly true for cancer treatment, where costs afforded for the development of targeted therapies impede their availability for all the potentially responsive patients. In this scenario, drug repositioning ( Langedijk et al, 2015 ; Sleire et al, 2017 ) represents one of the new strategies used to maximize the efficiency of the drug development process, allowing a faster and less expensive bench-to-clinic translation, and to minimize risks of unexpected toxicities ( Kim et al, 2016 ; Nosengo, 2016 ; Wurth et al, 2016 ). This approach is aimed to identify novel therapeutic indications for drugs previously approved for different uses.…”
Section: Introductionmentioning
confidence: 99%
“…This is particularly true for cancer treatment, where costs afforded for the development of targeted therapies impede their availability for all the potentially responsive patients. In this scenario, drug repositioning ( Langedijk et al, 2015 ; Sleire et al, 2017 ) represents one of the new strategies used to maximize the efficiency of the drug development process, allowing a faster and less expensive bench-to-clinic translation, and to minimize risks of unexpected toxicities ( Kim et al, 2016 ; Nosengo, 2016 ; Wurth et al, 2016 ). This approach is aimed to identify novel therapeutic indications for drugs previously approved for different uses.…”
Section: Introductionmentioning
confidence: 99%
“…The promise and challenges of implementing this technology has also been covered in CBT (Devine and Patani 2017;Kim et al 2016;Driessen et al 2017). Devine and Patani provided a very useful, focused overview of the application of iPSC technology for neurological applications.…”
Section: Implementation Of Induced Pluripotent Stem Cell/cell Reprogrmentioning
confidence: 99%
“…It can be hypothesized that small molecules which have been previously shown to induce proliferation in differentiated mammalian cells, such as cardiomyocytes, could be combined with myotube fragmentation compounds to achieve cellularization. In our laboratory, we tested the compound, BIO (Table 1), an inhibitor of glycogen syntheses kinase‐3β (GSK‐3β), which was previously shown to increase proliferation in refractory mammalian cardiac muscle cells [31,32]. Sequential treatment of mouse primary myotubes with myoseverin and BIO induced cellularization [33].…”
Section: Small Molecules Used To Induce Cellularization a Key Step Omentioning
confidence: 99%