Some new aspects in the application of perfluoroalkyl halides in the synthesis of fluorine-containing organic compounds

Selective fluoroalkylation of thiophenols by 1,2-dibromotetrafluoroethane activated by sulfur dioxide

“…Introduction of halocarbon fragments, containing other halogen atoms besides fluorine, into different organic substrates allows the synthesis of new polyfluoroalkyl substrates as well as transformation of fluorine containing substituents to more complex groups [1][2][3][4][5][6][7][8][9][10][11][12][13][14].…”

New synthesis of polyfluoroalkyl racemic α-amino acids

“…Several chemical sources such as peroxides, azonitriles, redox systems, metals or transition metal complexes, currently used to efficiently generate perfluoroalkyl radicals starting from R F I, have been reviewed [32,33]. Thus, a large variety of unsaturated molecules containing functional groups can undergo iodoperfluoroalkylation involving a radical pathway.…”

Multiple-fold C–F bond functionalization for the synthesis of (hetero)cyclic compounds: fluorine as a detachable chemical handle

“…29 Perfluoroalkyl halide R f –X (PFH, X = Br, I), as a low-toxic, stable, inexpensive, and environmentally friendly perfluoroalkyl source, has been extensively utilized as an efficient perfluoroalkyl radical precursor in the perfluoroalkylation reaction. 30–32 Despite direct homolysis of R f –X bond through SET process, the notorious C–F bonds in PFHs could also be cleaved for the heterocycle and carbocycle construction based on a sequence of radical-type fluoroalkylation and concomitant polar defluorinative cyclization (Scheme 4).…”