Some New Behaviour-disrupting Amphetamines and their Significance

Cross-tolerance Between Para-bromo-methamphetamine (V-111) and LSD-25

“…This conclusion is in good accordance with the psychotomimetic effect of some phenylalkylamine structures in animals or in man [Shulgin, 1963[Shulgin, , 1964Shulgin et al, 1969;Pc ret z et al, 1955;Smythies et al, 1967;Snyder et al, 1967;Florio et al, 1969]. Among the new derivativessynthetized by us, p-bromo-methamphetamine (V -lll), a compound possessing about one tenth of LSD activity in animals, was selected for detailed pharmacological in vestigations Ecseri, 1965, 1966;Knoll, Vizi and Knoll, 1968;Knoll, Vizi and Knoll, in press].…”

4-Bromo-2,5-Dimethoxyphenylisopropylamine, a New Centrally Active Amphetamine Analog

“…Although Smythies et al [12] have reported that p-methoxyphenylisopropylamine exhibits 'LSD-like' potency in rats, clinical experiments have shown it to be no more potent than either of the dimethoxylated (2,4-or 2,5-) or the tetramethoxylated analogs; all of these are distinctly less active than several of the trimethoxy counterparts [9,11], A number of compounds have been described that differ from one an other only in the identity of the substituent in the para (4-) position, while retaining the 2,5-dimethoxy substitution pattern. 2,4,5-Trimethoxyphenylisopropylamine (TMA-2), with a methoxyl group in the 4-position, is the most potent of the trimethoxyphenylisopropylamines [11]; the 4-ethoxy homolog is fully active [10], while a hydrogen at this position halves the potency.…”

Amphetamine Metabolism in Amphetamine Psychosis*

“…Shulgin (12) has demonstrated that p-methoxyamphetamine, a hypothetical metabolite of amphetamine, is a hallucinogen. Smythies (13) has proposed that p-methoxyamphet-amine may be formed from amphetamine during abuse of this compound and that p-methoxyamphetamine may be the toxic agent in amphetamine psychosis. In surveys carried out in our laboratory on amphetamine abusers, as well as with subjects to whom large doses of amphetamine was administered, p-methoxyamphetamine could not be identified (2).…”