Some Nucleophilic Substitutions in 2‐Cyano‐3‐nitroimidazo[1,2‐a]pyridine.

Abstract

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Effect of the lipophilic parameter (log P) on the anti-parasitic activity of imidazo[1,2-a]pyridine derivatives

“…13 C NMR d 19.0,114.8,115.85,117.75,130.47,137.51,137.56,143.35,162.39. C 9 The title compound was prepared following a procedure in the literature (Arias et al, 2006) and isolated as reddish crystals in 80% yield, mp: 167-168 and 162°C (Winkelmann et al, 1977).…”

“…The title compound was obtained from 2-carboxamido-5-methyl-3-nitroimidazo[1,2-a]pyridine, following the same procedure (Arias et al, 2006) …”

“…The title compound was prepared according to the same procedure and isolated as a yellow solid in 62% yield, mp: 156-158 and 157-159°C (Arias et al, 2006). (12) 5-Methyl-3-nitroimidazo[1,2-a]pyridine-2-carbonitrile was heated with an excess of cyclohexylamine, following the same procedure (Arias et al, 2006) …”

“…(12) 5-Methyl-3-nitroimidazo[1,2-a]pyridine-2-carbonitrile was heated with an excess of cyclohexylamine, following the same procedure (Arias et al, 2006) …”

Docking simulations, synthesis, and anti-inflammatory activity evaluation of 2-(N-alkyl)amino-3-nitroimidazo[1,2-a]pyridines

“…Isolated as pale yellow crystals following the literature protocol (Arias et al, 2006), in 40% yield, mp 164, 162°C (Teulade et al, 1978).…”