Some Nutritional and Physiological Factors Affecting the Urinary Excretion of Acid Soluble Peptides in Rats and Women

Noguchi, Tadashi; Okiyama, Atsushi; Nishimura, Hiroshi; Kaneko, Kayoko; Koike, Goro

doi:10.1080/00021369.1982.10865511

Cited by 3 publications

(5 citation statements)

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“…Although excretion of ASP-form amino acids increased in the diabetic rats, the amino acid pattern of ASP did not change significantly (results not shown). These findings are consistent with those reported previously (Noguchi et al 1982), although the method to determine ASP-form amino acids was different. Table 3 shows changes in urinary excretion of W-methylhistidine (3MH) in diabetic and , 19670).…”

Section: R E S U L T Ssupporting

confidence: 92%

“…Streptozotocin injection significantly affected the urinary excretion of 3MH whereas diet did not. The increased excretion of 3MH in the diabetic rats is consistent with our previous observations (Nagasawa et al 1982;Noguchi et al 1982). In our previous paper (Noguchi et al 1988), we suggested that in many instances urinary excretion of ASPform amino acids correlates with that of 3MH, but in other instances it does not.…”

Section: R E S U L T Ssupporting

confidence: 92%

“…, 1988. The excretion rate was proportional to metabolic body size in women and rats (Noguchi et al 1982). Furthermore, the urinary N:ASP ratio correlates with the efficiency of utilization of dietary N (Noguchi et al 1988).…”

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confidence: 92%

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Changes in the urinary excretion of acid-soluble peptides in rats injected with streptozotocin or dexamethasone: a trial to estimate the changes in the rate of whole-body protein degradation in those rats

1991

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Urinary excretion of acid-soluble peptides (ASP) was measured in rats given streptozotocin or dexamethasone. Streptozotocin-induced diabetic rats excreted increased amounts of urinary nitrogen and ASP-form amino acids. The urinary ratio for N: ASP-form leucine plus valine, which has been shown to reflect the efficiency of dietary N utilization, increased in the diabetic rats, suggesting the impaired utilization of dietary N (and re-utilization of endogenous N). Dexamethasone administration to adrenalectomized rats caused increased excretion of urinary ASP-form leucine plus valine with a concomitant increase in N excretion. However, urinary ratio for N:ASP-form leucine plus valine did not change significantly. The results suggested that dexamethasone caused increased degradation of body proteins, but maintained the efficiency of dietary N utilization or re-utilization of endogenous N. Based on the present observations and the hypothesis proposed previously by the present authors (Noguchi et al. 1988) that urinary excretion of ASP-form leucine plus valine reflects the rate of whole-body protein degradation and the urinary ratio for N: ASP-form leucine plus valine represents N utilization, the origin of urinary N in streptozotocin-diabetic and dexamethasone-administered rats is discussed.

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Section: R E S U L T Ssupporting

confidence: 92%

Section: R E S U L T Ssupporting

confidence: 92%

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Changes in the urinary excretion of acid-soluble peptides in rats injected with streptozotocin or dexamethasone: a trial to estimate the changes in the rate of whole-body protein degradation in those rats

1991

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“…The ASP were prepared according to the procedure described previously. 34) Determination of amino acids. The amount of ASPform amino acids was analyzed after acid hydrolysis with 6 N HCI for 24 hr at 105°C, using an amino acid analyzer (Hitachi 835-50, Hitachi Co., Tokyo, Japan).…”

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confidence: 99%

Effects of Bestatin and Leupeptin on Protein Degradation in Perfused Rat Hindquarters: Accumulation of Acid Soluble Peptides in Muscle during Bestatin Perfusion

Sonaka

Takahashi

Kadowaki

et al. 1984

Agricultural and Biological Chemistry

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“…Previously we reported that the urinary excretion of acid-soluble peptides (ASP) is potentially an excellent index of whole body protein degradation (Noguchi et a/. 1982(Noguchi et a/.…”

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Correlation between the urinary excretion of acid-soluble peptides, fractional synthesis rate of whole body proteins, and plasma immunoreactive insulin-like growth factor-l/somatomedin C concentration in the rat

Nam

Noguchi

Funabiki³

et al. 1990

Br J Nutr

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The relations between the urinary excretion of acid-soluble peptide (ASP)-form amino acids, the rate of whole body protein synthesis and plasma immunoreactive insulin-like growth factor-1 /somatomedin C concentration were investigated in rats. The urinary ASP-form leucine plus valine excretion correlated well with the rate of whole body protein synthesis and with the plasma immunoreactive insulin-like growth factor-1 concentration. The results provide further evidence for the hypothesis that urinary excretion of ASP is an excellent index of the status of protein metabolism in animals.Insulin-like growth factor-1 : Protein synthesis : Acid-soluble peptides : Rat Previously we reported that the urinary excretion of acid-soluble peptides (ASP) is potentially an excellent index of whole body protein degradation (Noguchi et a/. 1982(Noguchi et a/. , 1988. Based on observations of the relationship between urinary excretion of ASP and total nitrogen under various nutritional conditions, we proposed a hypothesis for the assessment of protein metabolism. The hypothesis contained two assumptions : the first was that urinary excretion of ASP is proportional to the rate of whole body protein degradation, the second was that the ratio of urinary N: ASP is linearly correlated with the efficiency of dietary N utilization at the recommended requirement level of dietary protein.(i.e. If the dietary protein level exceeded the recommended level, the ratio increased according to the increase in dietary protein content, even in the rats fed on the casein diets.) It has been shown by several authors that the fractional rate of tissue (for example, muscle) or whole body protein synthesis (or fractional rate of tissue growth or protein gain) is positively correlated with the fractional rate of their protein degradation (i.e. tissues which are actively synthesizing their proteins also degrade their proteins actively) if animals are not suffering from special degenerative diseases or are not given drugs such as glucocorticoid or thyroid hormones (Millward et a/.

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Some Nutritional and Physiological Factors Affecting the Urinary Excretion of Acid Soluble Peptides in Rats and Women

Cited by 3 publications

References 1 publication

Changes in the urinary excretion of acid-soluble peptides in rats injected with streptozotocin or dexamethasone: a trial to estimate the changes in the rate of whole-body protein degradation in those rats

Changes in the urinary excretion of acid-soluble peptides in rats injected with streptozotocin or dexamethasone: a trial to estimate the changes in the rate of whole-body protein degradation in those rats

Effects of Bestatin and Leupeptin on Protein Degradation in Perfused Rat Hindquarters: Accumulation of Acid Soluble Peptides in Muscle during Bestatin Perfusion

Correlation between the urinary excretion of acid-soluble peptides, fractional synthesis rate of whole body proteins, and plasma immunoreactive insulin-like growth factor-l/somatomedin C concentration in the rat

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