Some Observations on Headache

Northfield, D. W. C.

doi:10.1093/brain/61.2.133

Cited by 69 publications

(27 citation statements)

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“…This preferential dorsal location is consistent with the finding that 8 of 9 nociceptive cells in our study had RFs restricted to V1, while the majority (80%) of cells with SSS input and nociceptive RFs involved V1. Moreover, our findings are consistent with clinical studies in humans showing that stimulation of cranial vessels (Northfield 1938;Penfield and McNaughton 1940;Ray and Wolff 1940) or surrounding dura (Wirth and Van Buren 1971) causes pain predominantly in the V1 division. Davis and Dostrovsky did not localise any nociceptive units to VPM although they did find units there which they labelled "tap" and which they postulated may be nociceptive units masked by the anaesthetic.…”

Section: Discussionsupporting

confidence: 91%

“…Stimulation of cranial vessels such as the superior sagittal sinus (SSS) and the middle meningeal artery (MMA) in conscious humans causes headache (Northfield 1938;Penfield and McNaughton 1940;Ray and Wolff 1940). Early histological studies in monkeys and humans (Penfield and McNaughton 1940;Feindel et al 1960) showed that the sensory nerves supplying these vessels, the dural nerves, contain small diameter myelinated and unmyelinated fibres, most of which are probably nociceptive in function, as well as some larger diameter myelinated nerves.…”

Section: Introductionmentioning

confidence: 99%

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Stimulation of cranial vessels excites nociceptive neurones in several thalamic nuclei of the cat

Zagami

Lambert

1990

Exp Brain Res

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Extracellular recordings were made in the thalamus of cats anaesthetized with chloralose and urethane following electrical, mechanical and chemical stimulation of the superior sagittal sinus or middle meningeal artery. Facial receptive fields were looked for using electrical and mechanical stimuli. The locations of fifty-six cells were verified histologically. Twenty six cells were located in the ventroposteromedial nucleus (VPM) and six in its ventral periphery (VPMvp). All units in VPM had facial receptive fields, usually involving the first trigeminal division. Cells with nociceptive receptive fields or responding to the craniovascular application of bradykinin were often found in the periphery or "shell" region of VPM. Other craniovascular nociceptive cells were found in VPMvp, in the posterior group and in the intralaminar complex. This study shows that craniovascular afferents in the cat project to several thalamic nuclei and implicate VPM especially in craniovascular nociception.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Stimulation of cranial vessels excites nociceptive neurones in several thalamic nuclei of the cat

Zagami

Lambert

1990

Exp Brain Res

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“…In four of five patients, Northfield 9 noted that pressure or displacement of the ICA adjacent to the anterior clinoid process resulted in pain behind the ipsilateral eye or in the ipsilateral temple. Fay 10 noted that "electric stimulations, clamping, or traction of the large arterial branches produced ipsilateral pain referred deep in the eye, vaguely distributed to the temples, as is the case with the middle meningeal and middle cerebral arteries."…”

Section: Discussionmentioning

confidence: 98%

Focal headache during balloon inflation in the internal carotid and middle cerebral arteries.

Nichols

Mawad

Mohr

et al. 1990

Stroke

103

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“…A few early reports in humans have identified fine branches connecting the internal carotid artery with the medial surface of the ophthalmic nerve shortly rostral to the ganglion, but it was not clarified whether such fibers were of sympathetic or sensory origin. 28 - 30 Recently, a pathway between the ophthalmic nerve and the plexus has been demonstrated in humans, as well as a probable extension of the pathway to the intracavernous internal carotid artery. 19 Substantial levels of CGRP and substance P are found in this segment of the artery in humans.…”

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confidence: 99%

Pathways of parasympathetic and sensory cerebrovascular nerves in monkeys.

Hardebo

Arbab

Suzuki

et al. 1991

Stroke

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Using immunohistochemistry, we studied the origins and pathways of parasympathetic and sensory nerve fibers to the pial arteries in four squirrel monkeys. Following its application to the surface of the middle cerebral artery, the retrograde axonal tracer True Blue accumulated in parasympathetic neurons of the sphenopalatine ganglion and the internal carotid ganglion. The latter is strategically located where the internal carotid artery enters the cranium. Fibers from the sphenopalatine ganglion reach the internal carotid artery in the cavernous sinus region after running as rami orbitales. Before reaching the internal carotid artery, the fibers bypass aberrant sphenopalatine ganglia, with the most distant, the cavernous ganglion, being located in the cavernous sinus region. True Blue also accumulated in sensory neurons of the ophthalmic and maxillary divisions of the trigeminal ganglion and in sensory neurons of the internal carotid ganglion. Fibers from the ophthalmic division of the trigeminal ganglion reach the internal carotid artery as a branch through the cavernous sinus, bypassing the cavernous ganglion. Fibers from the maxillary division also bypass the cavernous ganglion after reaching it via a recurrent branch of the orbitociliary nerve. Thus, the cavernous ganglion forms a confluence zone for parasympathetic and sensory fibers in the region. In addition, parasympathetic and sensory fibers leave the confluence zone to follow the abducent and trochlear nerves backward to the basilar artery and tentorium cerebelli, respectively. Clinical implications are discussed. (Stroke 1991^2:331-342) B lood vessels of the brain surface, and to some extent those of its parenchymal branches, are supplied with sympathetic, parasympathetic, and sensory nerve fibers, spreading like a network in the adventitia.1 It has been long known that all sympathetic fibers (except those in the caudal basilar artery in some species) originate in the superior cervical ganglion.1 An origin for parasympathetic fibers in the sphenopalatine and otic ganglia has been demonstrated in rats and cats by the retrograde axonal tracer technique, by nerve section, and by histochemical mapping of the putative transmitters acetylcholine (cholinesterase, choline acetyltransferase [ChAT]) and vasoactive intestinal polypeptide (VIP).2 -5 By this latter technique (histochemical staining of the putative transmitters substance P and calcitonin geneFrom the

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Some Observations on Headache

Cited by 69 publications

References 0 publications

Stimulation of cranial vessels excites nociceptive neurones in several thalamic nuclei of the cat

Stimulation of cranial vessels excites nociceptive neurones in several thalamic nuclei of the cat

Focal headache during balloon inflation in the internal carotid and middle cerebral arteries.

Pathways of parasympathetic and sensory cerebrovascular nerves in monkeys.

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