Some pharmacokinetic data about furaltadone and nitrofurazone administered orally to preruminant calves

Nouws, J. F. M.; Vree, T. B.; Aerts, M.M.L.; Degen, Michael; Driessens, F. C. M.

doi:10.1080/01652176.1987.9694102

Cited by 7 publications

(4 citation statements)

References 7 publications

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“…It is noteworthy that refrigeration at 4°C did not curtail the degradation process in muscle tissues, which was proved by investigation of the M. longissimus dorsi at 24 h after slaughter. Monitoring methods based on drug investigation of organs and muscle tissues are thus unsuitable in the detection of the parent nitrofurans, but plasma and/or urine samples, prepared immediately after slaughter as described (2,5), are more suitable matrices. Since no parent nitrofurans are left in edible tissues of slaughtered animals, the discussion concerning the potential public health hazard of the parent drug 8 products of nitrofurans.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover in the EEC the 1 ppb tolerance level for the parent drug in edible tissues is under discussion. For monitoring purposes, sensitive and specific HPLC methods for detection of the parent drug in edible tissues have been developed (2,5). Recently it has been shown, that in vitro degradation of nitrofurans could be prevented by homogenising these tissues in 1.5 M phosphate solution (pH 4.5), containing 0.2% sodium azide (2).…”

Section: Introductionmentioning

confidence: 99%

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Postmortal degradation of furazolidone and furaltadone in edible tissues of calves

Nouws¹,

Laurensen²

1990

Veterinary Quarterly

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SUMMARY Rapid and complete postmortal degradation of furazolidone and furaltadone occurred in liver, kidney and muscle tissues of veal calves. Different degradation half-lives were observed between these tissues, the mean ranging from less than 7 minutes to 63 minutes. At 24 h after slaughter the parent nitrofurans were no longer detectable in edible tissues. For residue monitoring purposes plasma and/or urine can be used, if these matrices are treated in a specific way immediately after slaughter; muscle tissues and organs are unsuitable for residue monitoring of parent nitrofurans.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Postmortal degradation of furazolidone and furaltadone in edible tissues of calves

Nouws¹,

Laurensen²

1990

Veterinary Quarterly

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“…In contrast, little is known about FTD, a nitrofuran antibiotic primarily used for bacterial infections in poultry ( Nouws et al , 1987 ). Currently, nitrofurans are prohibited in the EU for livestock production due to their potential carcinogenicity.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic assays in yeast and zebrafish reveal drugs that rescue ATP13A2 deficiency

Heins-Marroquin

Jung

Cordero-Maldonado

et al. 2019

Brain Communications

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Mutations in ATP13A2 (PARK9) are causally linked to the rare neurodegenerative disorders Kufor-Rakeb syndrome, hereditary spastic paraplegia and neuronal ceroid lipofuscinosis. This suggests that ATP13A2, a lysosomal cation-transporting ATPase, plays a crucial role in neuronal cells. The heterogeneity of the clinical spectrum of ATP13A2-associated disorders is not yet well understood and currently, these diseases remain without effective treatment. Interestingly, ATP13A2 is widely conserved among eukaryotes, and the yeast model for ATP13A2 deficiency was the first to indicate a role in heavy metal homeostasis, which was later confirmed in human cells. In this study, we show that the deletion of YPK9 (the yeast orthologue of ATP13A2) in Saccharomyces cerevisiae leads to growth impairment in the presence of Zn2+, Mn2+, Co2+ and Ni2+, with the strongest phenotype being observed in the presence of zinc. Using the ypk9Δ mutant, we developed a high-throughput growth rescue screen based on the Zn2+ sensitivity phenotype. Screening of two libraries of Food and Drug Administration-approved drugs identified 11 compounds that rescued growth. Subsequently, we generated a zebrafish model for ATP13A2 deficiency and found that both partial and complete loss of atp13a2 function led to increased sensitivity to Mn2+. Based on this phenotype, we confirmed two of the drugs found in the yeast screen to also exert a rescue effect in zebrafish—N-acetylcysteine, a potent antioxidant, and furaltadone, a nitrofuran antibiotic. This study further supports that combining the high-throughput screening capacity of yeast with rapid in vivo drug testing in zebrafish can represent an efficient drug repurposing strategy in the context of rare inherited disorders involving conserved genes. This work also deepens the understanding of the role of ATP13A2 in heavy metal detoxification and provides a new in vivo model for investigating ATP13A2 deficiency.

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“…However, in this study, the metabolites formed remained unknown as further analysis using LC-MS is required. According to Nouws et al, [17], there are two main degradation pathways of the nitrofuran (Fig. 7), one is in the 5-nitrofuran ring and the other is at the side chain R where the metabolites are bound.…”

Section: Hplc-dad Analysismentioning

confidence: 99%

Biotransformation of Furaltadone, Furazolidone and Nitrofurazone using Aspergillus Tamarii isolate TN-7 : in Vitro Residual Identification and Quantification by HPLC-DAD

Mohammad¹,

Halim²,

Mahat³

et al. 2019

IJET

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Nitrofurans (NFs) such as furaltadone (FTD), furazolidone (FZD) and nitrofurazone (NFZ) have been used as antibacterials and growth promoters for the poultry and aquaculture industry. These antibiotics have now been banned from use due to their carcinogenic properties; therefore there is an urgent need to remove or degrade NFs from contaminated areas. Aspergillus tamarii isolate TN-7 isolated from antibiotic overexposed soil shows an ability to degrade the NFs antibiotics. After 5 days of incubating of Aspergillus tamarii isolate TN-7 with 500 µg/mL NF, the residual of the NF concentration was determined by High-Performance Liquid Chromatography-diode array detector (HPLC-DAD). Solid phase extraction was performed to clean-up the fermentation broth prior to HPLC-DAD analysis. Antimicrobial of the NFs residues showed a decreased in the percentage of inhibition that FTD, FZD and NFZ were reduced to to 85.71 %, 75.86 % and 70.97 % after 96 hours of incubation. Quantification using HPLC-DAD showed, after 96 hours of incubation, Aspergillus tamarii isolate TN-7 reduced furaltadone, furazolidone and nitrofurazone to 86.73 %, 37.49 % and 29.17 % respectively. This finding shows that Aspergillus tamarii isolate TN-7 has the potential to be used as a bioremediation tool in removing NF antibiotics from the contaminated areas.

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Some pharmacokinetic data about furaltadone and nitrofurazone administered orally to preruminant calves

Cited by 7 publications

References 7 publications

Postmortal degradation of furazolidone and furaltadone in edible tissues of calves

Postmortal degradation of furazolidone and furaltadone in edible tissues of calves

Phenotypic assays in yeast and zebrafish reveal drugs that rescue ATP13A2 deficiency

Biotransformation of Furaltadone, Furazolidone and Nitrofurazone using Aspergillus Tamarii isolate TN-7 : in Vitro Residual Identification and Quantification by HPLC-DAD

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