Some Pharmacological Actions of Piperidine, Pyrrolidine, and of Pressor Concentrates From Dog Urine

Lockett, Mary F.

doi:10.1111/j.1476-5381.1949.tb00523.x

Cited by 21 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since piperidine and pyrrolidine exhibit a variety of pharmacological actions (Lockett 1949;Tecwyn Williams 1959), the point of greatest interest in these results is the relatively high concentration of piperidine, and the presence of pyrrolidine, in rumen liquor. For cows fed red clover, a small portion of the piperidine could arise from that present in the herbage.…”

Section: Discussionmentioning

confidence: 99%

Steam-volatile amines in rumen liquor from cattle and sheep

Fraser¹,

Butler²

1964

New Zealand Journal of Agricultural Research

View full text Add to dashboard Cite

The steam-volatile amines present in rumen liquor of cattle fed red clover and sheep grazing ryegrass have been separated and identified, Piperidine was invariably the predominant amine. Pyrrolidine, isobutylamine, isoamylamine, ,B-phenylethylamine, ethylamine, and ethanolamine were also present. The pattern of amines observed was a fairly constant one, although individual amines varied considerably in concentration. Piperidine and other amines were also observed in extracts from red clover and ryegrass. The extent by which the amines arose directly from the feed or from de novo synthesis in the rumen is discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

Steam-volatile amines in rumen liquor from cattle and sheep

Fraser¹,

Butler²

1964

New Zealand Journal of Agricultural Research

View full text Add to dashboard Cite

show abstract

“…Piperidine (Pip) is a normal constituent of brain (1,2,3,4,5,6,7), skin (8,9) and urine (3,10) of mammals, and of the brain (11), cerebrospinal fluid (12), and urine (3,10,13) of humans, and of cerebral ganglia of molluscs (14). Pip shows potent nicotine-like actions on the peripheral (15,16,17) and central nervous systems (CNS) (18,19). Pip acts on the autonomic ganglia, neuromuscular junctions and chemoreceptors, i.e., it elicits stimulation in small doses and depression in large doses.…”

mentioning

confidence: 99%

“…of biogenic amines possessing potent pharmacological and physiological actions(15)(16)(17)(18)(19)(20)(21)(22). The present study was undertaken to determine the metabolic fate of Pip in the living body.Five peaks (M1-M5) appeared on the radiochromatogram of the sample obtained from urine of rats administered 3H-Pip.…”

mentioning

confidence: 99%

Metabolites of Piperidine in Rat Urine

Okano

Miyata

Hung

et al. 1978

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

Abstracts-Piperidine is one of pharmacologically active biogenic amines While two pathways for piperidine production have been reported, little is known about me tabolism of the compound.In the present study, piperidine and its hydroxylated, conjugated and unknown metabolites were detected in rat urine by radiochromato graphic analysis. Using GC-MS technique, it was confirmed that 3-hydroxypiperidine and 4-hydroxypiperidine are major metabolites of piperidine of either exogenous or endogenous origin. The findings substantiate the existence of a mechanism which inactivates piperidine in the living body, since both metabolites lack the potent phar macological activities as those induced by piperidine.

show abstract

“…2 It shows potent nicotine-like actions on the peripheral and central nervous systems. 3 It has also been suggested that piperidine affects neural mechanisms governing the regulation of emotional behavior, sleeping and extrapyramidal function. 4 The title compound was synthesized from dimedone (1.40 g, 10 mmol) taken in 30 ml of DMF.…”

mentioning

confidence: 99%