Some Pharmacological Studies of Ciproflo

Abstract

This study was conducted to investigate some pharmacological effects of ciprofloxacin and levofloxacin in their therapeutic and double therapeutic doses on healthy male albino rats. Forty five rats were divided into 5 groups, each of 9 rats, 1 st was left as a control, 2 nd and 3 rd groups received 100 mg/kg BW ciprofloxacin and levofloxacin respectively, orally for 10 successive days (therapeutic dose). The 4 th and 5 th groups were administrated 200 mg/kg ciprofloxacin and levofloxacin respectively, orally for 10 successive days (double therapeutic doses). Urine analysis and serum biochemical parameters were estimated in addition to histopathological examination of liver and kidneys. The urine analysis revealed that levofloxacin at its therapeutic and double therapeutic doses produced a significant increase in urinary proteins, blood, bilirubin, urobilinogen and urinary ketones while ciprofloxacin doses produced less damage. However, serum biochemical parameters disclosed that levofloxacin is a safer fluoroquinolone than ciprofloxacin; these results were confirmed by histopathological examination of liver and kidneys. Urine analysis despite widely used in human laboratories, it is not a reliable technique; blood biochemical parameters examination and histopathological examination are more dependable.

Title: Effect of Curcumin and Ginger on Adverse Effects of Levofloxacin in Male Rats

“…The hypoproteinemia and hypoalbuminemia evident in the present study may be attributed to liver damage and nephrotoxic effect induced by LFX resulting in severe reduction in protein synthesis by liver and also increases protein loss in urine by the kidney [52]. Our results were in agreement with other investigations [53].The obtained hyperglobulinemia is associated with liver damage induced by fluoroquinolones [54] or may be secondary to hypoalbuminemia or as autoantibodies against diseased liver cells [33].…”

“…Fluoroquinolones have been linked to allergic interstitial nephritis, acute tubular necrosis, acute renal failure, and crystalluria. The majority of these reactions are linked to the antibiotics ciprofloxacin, norfloxacin, ofloxacin, and LFX [6,7].…”

Nephroprotective effect of vitamin D Against Levofloxacin-induced renal injury: an observational study

“… Group III (positive control): Rats were treated with a single dose of Levofloxacin (100 mg/kg/day) I.P. for 14 days [ 21 ]. Group IV (negative control): Rats were orally administered a single dose of vitamin D3 (500 IU/rat/day) for twenty-one days [ 22 ].…”

“… Group V: Rats were orally administered vitamin D3 (500 IU/rat/day orally for twenty-one days, and I.P. levofloxacin (50 mg/kg/day) was injected on day 8 for 14 days [ 21 , 22 ]. Group VI: Rats were treated orally with vitamin D3 500 IU/rat/day for twenty-one days, and I.P.…”

“… Group VI: Rats were treated orally with vitamin D3 500 IU/rat/day for twenty-one days, and I.P. levofloxacin 100 mg/kg/day injected at day 8 for fourteen days [ 21 , 22 ]. …”