Some Potential Antiviral Agents*

Synthesis and anti‐HIV activity of new 2‐thiolumazine and 2‐thiouracil metal complexes

“…4-Amino-2-thiouracil, for example, a thiopyrimidine derivative, exhibited antiviral and chemotherapeutic activity [23]. Therefore, several laboratories have focused their interest on the synthesis of 2-thiouracil-metal complexes [24][25][26][27].…”

Biologically active 2-thione-4,6-diamino-5-hydroxypyrimidine transition metal complexes

“…Many studies reported that 2-thiopyrimidine and 4-amino-2-thiopyrimidine are similar to 2-thiopyrimidine in nucleotides [2][3][4]. Furthermore, they are able to inhibit the synthesis of t-RNA [5] and act as valuable starting materials in the synthesis of antibacterial, antifungal and anticancer chemotherapeutic agents [6][7][8].…”

Structure and Antiviral Activity of Substituted Potassium Benzylaminothiomethane‐sulphonates and Allied Compounds*

“…Chick embryos: embryonated white Leghorn hen eggs 10 or 11 days old were used. The cultivation of viruses in chick embryos, the procedures for screening of compounds in ova and in vivo for antiviral activity and other experimental details have been described earlier (Krishnamurthy, Nageswara Rao, Narasimha Rao & Praphulla, 1967 the isothiocyanate (0.5 g) with potassium metabisulphite (0.5 g) for 5 hr in aqueous ethanol (50%, 10 ml.) as described by Backer, Mulder & Froentjee (1935).…”

“…), cooled in ice. The stirring was continued for 10 min more and the precipitate was washed with aqueous ethanol (40%) (Pillai, 1958 (Krishnamurthy et al, 1967), the following attempts were made to isolate and characterize the active principle: (a) The reactants were mixed in equimolar quantities and the pale yellow product dissolved in the minimum volume of ethyl acetate. By cooling to 0' C, a yellow substance separated, melting at 115-122' C (decomp.…”