Some Problems of Thalassemia in Jakarta

Wahidiyat, Iskandar; Markum, A. H.; Abdulsalam, M; Muslichan, S

doi:10.14238/pi18.3-4.1978.100-8

Cited by 3 publications

(4 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Figure 3 showed higher prevalence of short stature subjects in the older group (>10-18 years old) than that in the younger group. The result was consistent with other studies which were reported by Wahidiyat, 1 Wulandari, 14 and Purnama Dewi. 15 They found that growth disorders affected the older thalassemic children more than the younger group.…”

Section: Discussionsupporting

confidence: 93%

Relationships between plasma zinc and ferritin with nutritional status in thalassemic children

Arijanty¹,

Nasar²,

Madiyono³

et al. 2016

View full text Add to dashboard Cite

Background Repeated blood transfusions in thalassemic chil-dren can lead to iron overload in the body. High ferritin level leadsto low plasma zinc status because of their competitive inhibition.Previous study found that there was a correlation between plasmazinc level and nutritional status.Objective To obtain plasma zinc level, to investigate the correla-tion between plasma zinc and ferritin, and the impact of plasmazinc on nutritional status in children with thallasemia.Methods A cross sectional study was conducted on 67 thalas-semic children. This study was performed at Thalassemia Center,Cipto Mangunkusumo Hospital, Jakarta, from 1 st until 31 st of March2005. The age of the patients ranged from 4 to 18 years, with fer-ritin levels more than 2000 ng/ml during the last 6 months or totaltransfusion more than 5 liters. The subjects were divided into 2groups, i.e. group 1 (4-10 years) and group 2 (>10-18 years). Di-etary intake was assessed by 3 day-dietary recall. The nutritionalstatus were judged by mid upper arm circumference (MUAC) forage and height for age (H/A). Venous blood was obtained to mea-sure plasma zinc and ferritin levels. Statistical analysis was doneby Student’s t-test (2-tailed) and linear regression analysis.Results We found that 42% subjects were well-nourished, 51%were undernourished, and 7% were severely malnourished. All sub-jects had low plasma zinc status 31.9 (SD 16.9) μg/dl. There was aweak negative correlation between plasma zinc and ferritin level (r= -0.282, P=0.021). Lower zinc intake was detected in 65 out of 67subjects.Conclusion All thalassemic children in our hospital had low plasmazinc level. There was a weak negative correlation between plasmazinc level and ferritin level. There was no significant correlationbetween plasma zinc status and nutritional status

show abstract

Section: Discussionsupporting

confidence: 93%

Relationships between plasma zinc and ferritin with nutritional status in thalassemic children

Arijanty¹,

Nasar²,

Madiyono³

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In 1980, there were about 250 cases of thalassemia in the Department of Child Health in Jakarta. 9 At this time (2005) there are about 1100 patients who come regularly for blood transfusion, their age are ranging form 4 months to 36 years. 10 Most of the 250 patients have died already at the age of 7-8 years; several cases could reach the age of 17 years only.…”

mentioning

confidence: 99%

Genetic problems at present and their challenges in the future: Thalassemia as a model

Wahidiyat¹,

Wahidiyat²

2016

View full text Add to dashboard Cite

Compared to the infectious diseases, geneticdisorders are not so frequently encounteredin the clinic, so that there has been a trendthat they are neglected by people or evenby the authorities. Our government is still fightingagainst infectious diseases and nutritional disorders.The immunization programs of the government haveindeed reduced the occurence of many infectious dis-eases. Actually, the government has to begin to thinkhow to handle the emerging genetic disorders, afterhaving eradicating infectious diseases.

show abstract

“…1 Bentuk heterozigot biasanya secara klinis sukar dikenal karena tidak memperlihatkan gejala klinis yang nyata dan umumnya tidak memerlukan pengobatan. 1 Gangguan pertumbuhan pada pasien thalassemia disebabkan oleh berbagai faktor, antara lain faktor Pada thalassemia terjadi proses hemolisis sehingga terjadi anemia kronis yang mengakibatnya hipoksia jaringan. Hipoksia kronis menyebabkan gangguan penggunaan nutrien pada tingkat sel, sehingga terjadi gangguan pertumbuhan.…”

Section: Masalah Nutrisi Pada Thalassemiaunclassified

“…Anemia dan kekurangan gizi kronis diduga merupakan penyebab perawakan pendek. 1,3 Di dalam naskah ini akan dibahas mengenai masalah nutrisi pada kasus thalassemia.…”

unclassified

Masalah Nutrisi pada Thalassemia

Arijanty¹,

Nasar²

2016

View full text Add to dashboard Cite

Gangguan pertumbuhan pada thalassemia disebabkan oleh banyak faktor antara lain faktor nutrisi. Gangguan pertumbuhan akibat kekurangan gizi dapat menyebabkan perawakan pendek. Nutrisi yang adekuat sangat penting untuk pasien thalassemia sebagai modalitas dalam pengobatan jangka panjang dan untuk mencegah gangguan gizi, gangguan pertumbuhan, perkembangan pubertas dan defisiensi imun. Asupan nutrisi yang dianjurkan pada thalassemia adalah tinggi kalori, protein, kalium, seng, vitamin A,D, E, rendah besi sedangkan vitamin C harus dikurangi karena dapat meningkatkan absorpsi besi. Suplementasi vitamin C dosis rendah diberikan bersamaan dengan penggunaan desferoksamin untuk membantu meningkatkan pengeluaran besi.Kata kunci: thalassemia, nutrisi, tumbuh kembang.

show abstract

Some Problems of Thalassemia in Jakarta

Abstract: Within 10 years (1964 -1974) •two hundred and twenty one ' Beside the medical points of view thalassemia has also many social aspects to be considered, those of the cM1d itself, the parents and the society or community.

Cited by 3 publications

References 3 publications

Relationships between plasma zinc and ferritin with nutritional status in thalassemic children

Relationships between plasma zinc and ferritin with nutritional status in thalassemic children

Genetic problems at present and their challenges in the future: Thalassemia as a model

Masalah Nutrisi pada Thalassemia

Contact Info

Product

Resources

About