Some properties of the microsomal system metabolizing DDT in Triatoma infestans

Agosín, Manuel R.; Scaramelli, N.; Gil, Lionel; Letelier, María Eugenia

doi:10.1016/0010-406x(69)91629-6

Cited by 32 publications

(9 citation statements)

References 8 publications

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“…For insects, induction of a P450-dependent enzyme activity (Agosin et al, 1969) and of a specifi c P450 gene (Cariño et al, 1992) by phenobarbital were reported long ago. Molecular studies in several insect species have now identifi ed many phenobarbital-inducible genes (review in Feyereisen, 2005).…”

Section: Discussionmentioning

confidence: 99%

Xenobiotic response in Drosophila melanogaster: Sex dependence of P450 and GST gene induction

Goff

Hilliou

Siegfried

et al. 2006

Insect Biochemistry and Molecular Biology

146

109

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Section: Discussionmentioning

confidence: 99%

Xenobiotic response in Drosophila melanogaster: Sex dependence of P450 and GST gene induction

Goff

Hilliou

Siegfried

et al. 2006

Insect Biochemistry and Molecular Biology

146

109

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“…DDT exposure have been demonstrated to enhance mixed function oxidases (MFO) in T. infestans in the 60's by Agosin and Dinamarca (1963) and Agosin et al (1969). DDT was also found to be most active in causing GST activity induction (150%) in Musca domestica (Hayaoka & Dauterman 1982).…”

Section: Discussionmentioning

confidence: 99%

Induction of Glutathione S-transferase Activity in Triatoma infestans

Sívori¹,

Casabé²,

En³

et al. 1997

Mem. Inst. Oswaldo Cruz

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“…Although its presence in insects has been only recently reported (Ray, 1967), available evidence suggests that it also participates in insect microsomal hydroxylations (Perry, 1970;Mathews & Casida, 1970). The latter are important in resistance to several types of insecticides, especially since the enzyme(s) involved is induced by the same insecticides metabolized (Morello, 1964;Agosin, Scaramelli, Gil & Letelier, 1968).…”

mentioning

confidence: 99%

Cytochrome P-450 and hydroxylating activity of microsomal preparations from whole houseflies

Morello

Bleecker

Agosín

1971

Biochemical Journal

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1. A new microsomal preparation, obtained from whole houseflies is described in terms of its cytochrome P-450 content and its hydroxylating activity. 2. Microsomes prepared from whole-fly brei, obtained with the aid of a mortar (a procedure that avoids the destruction of sarcosomes), contain 0.265nmol of cytochrome P-450 and hydroxylate naphthalene at a rate of 28.5nmol/mg of microsomal protein in 30min at 30 degrees C. This corresponds to 104nmol of naphthalene hydroxylated/nmol of cytochrome P-450. This is the highest rate ever reported for housefly and rat liver microsomal preparations. 3. Microsomal fractions prepared by procedures that do not retain the integrity of sarcosomes show the presence in the CO-difference spectrum of a 428nm peak. This cytochrome is associated with sarcosomal microsomes and it may be involved in the inhibition of insect microsomal mixed-function oxidases, although other factors cannot be discarded at present. 4. The inability to show cytochrome P-450 in microsomal fractions isolated from whole houseflies by other procedures may be at least partially due to a masking effect brought about by contamination with the sarcosomal cytochrome.

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Some properties of the microsomal system metabolizing DDT in Triatoma infestans

Cited by 32 publications

References 8 publications

Xenobiotic response in Drosophila melanogaster: Sex dependence of P450 and GST gene induction

Xenobiotic response in Drosophila melanogaster: Sex dependence of P450 and GST gene induction

Induction of Glutathione S-transferase Activity in Triatoma infestans

Cytochrome P-450 and hydroxylating activity of microsomal preparations from whole houseflies

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