Some recently recognized manifestations of the rubella syndrome

Pathology of congenital rubella in Jamaica.

“…In spite of this, there are high antibody levels in the blood (Plotkin, Dudgeon, and Ramsay, 1963). In addition, there is evidence of immunological disturbance, as shown in levels of IgM and IgG (Bellanti, Artenstein, Olson, Buescher, Luhrs, and Milstead, 1965;Soothill, Hayes, and Dudgeon, 1966).…”

“…However, apart from isolated case reports (Lambert, Stern, and Wellsteed, 1965;Stern and Williams, 1966;Menser, Dorman, Reye, and Reid, 1966) pathological data have been limited to descriptions of certain organs or tissues as part of larger series of clinical studies (Plotkin, Oski, Hartnett, Hervada, Friedman and Gowing, 1965; Korones, Ainger, Gilles, Roane, Sever, and Fuste, 1965;Cooper, Green, Krugman, Giles, and Mirick, 1965), or to the pathology of abortuses (Tondury and Smith, 1966).…”

Congenital Rubella: Report of Two Cases with Generalized Infection

“…In Case 2 the liver biopsy performed at 4 months of age showed minimal histological changes, but rubella virus was isolated from the biopsy specimen. Multinucleated giant-cell transformation and hepatic necrosis in congenital rubella has been described (Plotkin, 1965).…”

Thymic hypoplasia due to congenital rubella.

“…Seligmann et al (1968) considered that intrauterine environmental factors can affect the development of the immunological functions and so cause immunological deficiencies. Plotkin et al (1965) suggested that the rubella virus may interfere with the development of the thymus and lymph nodes. Soothill, Hayes, and Dudgeon (1966) confirmed the high incidence of hypo-y-globulinaemia in the congenital rubella syndrome, suggesting a causal relation.…”