In this paper, we investigate the matrix analogues of the Ψ-beta and Ψ-gamma functions, as well as their properties. With the help of the Ψ-beta matrix function (BMF), we introduce the Ψ-Gauss hypergeometric matrix function (GHMF) and the Ψ-Kummer hypergeometric matrix function (KHMF) and derive certain properties for these matrix functions. Finally, the Ψ-Appell and the Ψ-Lauricella matrix functions are defined by applications of the Ψ-BMF, and their integral representations are also given.