In this paper, we study and introduce a self adaptive method together with a Halpern iterative algorithm for approximating solutions of multiple-sets split monotone variational inclusion problem which includes the multiple-sets split feasibility problem, split feasibility problem, split monotone variational inclusion problem and split variational inclusion problem, to mention a few. Using our iterative algorithm, we prove a strong convergence result for approximating the solution of the aforementioned problems. Numerical examples on finite-dimensional and infinite-dimensional spaces are displayed to illustrate the performance of our iterative method. The result discussed in this article extends and complements many related results in literature.