Some subtypes of endocannabinoid/endovanilloid receptors mediate docosahexaenoic acid-induced enhanced spatial memory in rats

Cognitive enhancement by omega-3 fatty acids from child-hood to old age: Findings from animal and clinical studies

“…Nonetheless, it shows that post-developmental DHA supplementation can restore effects of depletion. Similar to Pan et al (2011), it would be of interest to study more the effect of n-3 supplementation in rats fed n-3 adequate diets, to determine the true memory-enhancing potential of n-3 PUFA in healthy animals.…”

“…Pan et al (2011) measured the effect of increasing doses of DHA and found that appropriate doses (150 or 300 mg/kg/d) significantly improved learning and memory in the Morris water maze, but that a higher intake (600 mg/kg/d) increased memory impairment. Unique about this study is that the researchers used a control diet that was not deficient in n-3 PUFA, thus demonstrating a true supplementation effect of DHA.…”

Dietary Omega-6/Omega-3 and Endocannabinoids: Implications for Brain Health and Diseases

“…This suggests that imbalanced PUFAs content in the diet are compensated by enzymatic processes in the brain, but the question remains open for enzymes of the endocannabinoid system. One study reported that DHA supplementation increases levels of CB1 and TRPV1, in terms of mRNA expression and protein levels [109] (Figure 3). Recently, our laboratory demonstrated that a dietary ω-3 deficiency from gestation induces a desensitization of the CB1 receptor [7,8] (Figure 3).…”

The pleiotropic effects of omega-3 docosahexaenoic acid on the hallmarks of Alzheimer's disease

“…Such studies support the fact that DHA supplemented diet, as observed in humans, could improve the cognitive dysfunction due to aging [56][57][58][59][60][61][62]. In the study of Pan and colleagues, DHA (150 or 300 mg/kg/d) was also found to significantly improve learning and memory in young rats while a higher dose of DHA (600 mg/kg) increased the risk of memory impairment [63]. It has been shown, after a chronic DHA treatment, that DHA-induced improvement in spatial cognition in rats was associated with increased Fos expression in the CA1 hippocampus [64].…”