Some Toxic Effects of Aqeous Leaf Extract of Anogeissus leiocarpus in Rats

Agaie, B. M.; Onyeyili, P. A.; Muhammad, Bawa Yusuf; Ladan, MJ

doi:10.3923/jpt.2007.396.401

Cited by 10 publications

(10 citation statements)

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“…As observed, the methanol CE and ethyl acetate partitioned fraction of A. leiocarpus did not cause significant (P > 0.05) change in hematological parameters when compared to the basal control group (Figure 2). This finding corroborates the results obtained by Agaie et al and Chidozie et al (48,49) whose studies revealed that significant hematological changes were not observed in extract treated groups when compared to the control. However, it was agreed that A. leiocarpus possess potent pro-hematological agents capable of normalizing biochemical abnormalities associated with blood disorders (48,49).…”

Section: Discussionsupporting

confidence: 93%

“…This finding corroborates the results obtained by Agaie et al and Chidozie et al (48,49) whose studies revealed that significant hematological changes were not observed in extract treated groups when compared to the control. However, it was agreed that A. leiocarpus possess potent pro-hematological agents capable of normalizing biochemical abnormalities associated with blood disorders (48,49). Meanwhile, Sarkiyayi and Aileru (50) reported that methanol extract of the plant exhibited a dose-dependent increase in certain hematological parameters such as RBC count, platelet count, and MCH.…”

Section: Discussionsupporting

confidence: 93%

“…Enhanced cyclin D2 expression could potentially promote proliferation of hematopoietic stem and progenitor cells (74,75). This could explain the pro-hematological tendency of A. leiocarpus as reported by previous studies (48,49). However, cyclindependent kinase inhibitors (CKIs) inhibit cell division by antagonizing the activities of specific Cdks.…”

Section: Discussionsupporting

confidence: 54%

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Identification of the Anti-sickling Activity of Anogeissus leiocarpus and In Silico Investigation of Some of Its Phytochemicals

Elufioye

Williams

Cyrl-Olutayo

2020

Avicenna J Med Biochem

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Background: The anti-sickling activity of Anogeissus leiocarpus, a plant used for managing sickle cell disease (SCD), has been previously proven. Objectives: This study investigated the anti-sickling mechanism of A. leiocarpus by probing its effects on Gardos channel (KCNN4), erythropoietin (EPO), erythropoietin receptor (EPOR), catalase (CAT), G6pD, D-type cyclins and cyclin-dependent kinase inhibitors (p21) gene expression as well as assessing in silico drug-likeness of reported compounds as EPOR agonist. Methods: A total of 18 rats (45-76 g) were selected and divided into 6 groups (n=3). The control group was given water ad libitum, standard group was given 0.1 mL/kg of Ciklavit® and experimental group was given daily oral doses of 50-100 mg/kg body weight of crude methanol extract or ethyl acetate fraction (EA-PF). Haematological parameters were analyzed while histopathological and molecular studies of kidney and bone marrow were carried out, followed by RT-PCR analysis of KCNN4, EPO, EPOR, CAT, G6pD, p21, and cyclin-dependent kinase inhibitors. Docking studies of the reported compounds were also done. Results: EA-PF had an insignificant (P>0.05) effect on haematological parameters compared to the basal group. While CAT and p21 acted in a positive feedback loop, G6pD was downregulated in the experimental groups. KCNN4 acted in a negative-feedback mechanism and the upregulation of EPO and EPOR was followed by increased reticulocytes. Kaempferol, quercetin, and catechin showed non-violation of Lipinski’s rule and high binding affinities of 6.5 kcal/mol, 6.7 kcal/mol, and 6.7 kcal/mol, respectively, for EPOR pocket compared to the co-crystallized ligand. Conclusion: Results suggest that ethyl acetate fraction of Anogeissus leiocarpus achieved a steady state level of the Gardos channel and stimulation of EPO expression via EPOR agonist.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 54%

See 1 more Smart Citation

Identification of the Anti-sickling Activity of Anogeissus leiocarpus and In Silico Investigation of Some of Its Phytochemicals

Elufioye

Williams

Cyrl-Olutayo

2020

Avicenna J Med Biochem

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“…The concept of polyherbalism has been highlighted in Sharangdhar Samhita, an Ayurvedic literature dating back to 1300 AD. From the long-term traditional folk use and clinical applications, it is fairly understood that most herbal plants or products derived from them have an excellent safety record [45][46][47] . The diverse therapeutic properties of R. officinalis has incremented its use by the population by [48,49] , however the presence of chemical compounds, such as fl avonoids, that have been reported to have toxic by [50][51][52] and antifertility activities by [53,54] as well as the anti-implantation effect reported on female rats by [55] suggests a potential reproductive toxic role of this plant.…”

Section: Discussionmentioning

confidence: 99%

Acute oral toxicity study of “Polyherbal formulation (Rosmarinus officinals, Ashwaghandha and Amla) in Wistar rats”

Yallappa¹,

Kr²,

Fb³

et al. 2021

Int. J. Mosq. Res.

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Today in this present globe many part of the continents the use of herbal medicinal products and supplements has increased tremendously over the past three decades with not less than 80% of people worldwide trusting on them for some part of primary healthcare. The study was focused to evaluate the acute oral toxicity of polyherbal formulations (PHFs) and the developed polyherbal formulation includes three herbs viz. the roots of Withania somnifera (Ashwagandha), leaves of R. officinalis (Rosemary) and fruit of Emblica officinalis (Amla) detect the effect of this polyherbal formulation on higher mammals. The raw materials were standardized according to the WHO guidelines and the three holistic extracts were mixed in 1:1:1 ratio for further study by bio-guided method and also in combination to control and curing or managing of different diseases. However, to confirm the drug's safety and efficacy in the appropriate dosages we used healthy nulliparous and non-pregnant female Wister Albino rats (Rattus norvegicus) with average body weight of 160 g -180 g and age between 8-12 weeks were used throught the experiments in the present study administered a single dose of 2000mg/kg of body weight by oral gavage in female Wistar rats the observation period of 14 days. The rats were maintained under standard laboratory conditions (room temperature of 22.1 to 24.6°C with optimal air cycle changes 12-15 per hour and relative humidity of 48-61 % with 12 hours light & dark cycle). The animals were fed with laboratory animal feed and UV sterilized drinking water was provided ad-libitum throughout the experimental period. Hence the present study is designed to test the acute (limit dose) toxicity of two herbal extracts of rosemary leaf and ashwagandha and amla root in Wister rats following the OECD guidelines 423, which would help in suggesting the minimum safety level of herbal extracts.

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“…Ethnobotanical survey team has taken a commitment to share the data concerning monograph for five endangered medicinal plants from Burkina Faso. Burkina Faso [8] Its extract DL50 was1400mg/kg and was safely in bon-santé cleaner [9,10].…”

Section: Data Collectionmentioning

confidence: 99%

Availability Evaluation of Twelve Antimalarial Medicinal Plants from Western Regions of Burkina Faso

Compaoré¹

2018

JDMP

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Major research contributions in ethnopharmacology have generated vast amount of data associated with medicinal plants in Burkina Faso. Despite the relatively abundant literature on local medicinal plants supported by an institutional environment in favor of promoting traditional medicine, any national pharmacopoeia document or monographs on antimalarial medicinal plants aren't currently available. The aim of this study is to evaluate the knowledge and perception of traditional healers on the effectiveness and availability of 12 antimalarial plants from Burkina Faso. The survey was carried out on 12 antimalarial plants from western region during January-March 2013. The informants were 100 traditional healers and herbalist from the Western region, which gathered in association affiliated to General Directorate of Pharmacy, Medicines and Laboratories. A semi-structured and open questionnaire and herbarium were used for plant identification. The data showed that Securidaca longepedunculata (66%) and Zanthoxylum zanthoxyloides (64%) was the lowest available followed by Pavetta crassipes (57%), Argemone mexicana (48%) and Cochlospermum planchonii (44%). The root uses of C. planchonii (51%), S. longepedunculata (24%) and Z. zanthoxyloides (11%) were probably their threat. S. longepedunculata, Z. zanthoxyloides and P. crassipes are really in endangered due to their large medicinal uses particularly in malaria treatment. It need a new policy management and integrated breeding for these plants.

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Some Toxic Effects of Aqeous Leaf Extract of Anogeissus leiocarpus in Rats

Cited by 10 publications

References 1 publication

Identification of the Anti-sickling Activity of Anogeissus leiocarpus and In Silico Investigation of Some of Its Phytochemicals

Identification of the Anti-sickling Activity of Anogeissus leiocarpus and In Silico Investigation of Some of Its Phytochemicals

Acute oral toxicity study of “Polyherbal formulation (Rosmarinus officinals, Ashwaghandha and Amla) in Wistar rats”

Availability Evaluation of Twelve Antimalarial Medicinal Plants from Western Regions of Burkina Faso

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