Some Virological and Serological Observations On Marek’s Disease: A Preliminary Report

Rispens, B. H.; Vloten, Jacob P. van; Maas, H. J. L.

doi:10.1016/s0007-1935(17)48760-4

Cited by 27 publications

(14 citation statements)

References 5 publications

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“…For the second challenge, of only four birds in each group, the same amount of RSV (RAV-1) or RSV(RAV-2) was given intramuscularly. The origin of the LV strains, the procedures and maintenance of the cell cultures and media have been described previously (Rispens et al, 1969;Rispensef a/., 1972;Rispens et aL, 1976;de Boer era/., 1978a).…”

Section: Virus Cell Cultures and Mediamentioning

confidence: 99%

Age related resistance to avian leukosis virus. III. Infectious virus, neutralising antibody and tumours in chickens inoculated at various ages

Maas

Boer²,

Groenendal³

1982

Avian Pathology

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Section: Virus Cell Cultures and Mediamentioning

confidence: 99%

Age related resistance to avian leukosis virus. III. Infectious virus, neutralising antibody and tumours in chickens inoculated at various ages

Maas

Boer²,

Groenendal³

1982

Avian Pathology

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“…Challenge virus Strain K MDV, described by Rispens et al (1972) and Maas et al (1978), was used for challenge. The duck embryo fibroblast (DEF) tissue-culture system and methods have been described by Rispens et al (1969). Further details of the origin of strain K. are as follows: In 1968 ten pullets with clinical signs of MD were taken from a flock suffering from a severe outbreak of acute MD.…”

Section: Rjl Umsetalmentioning

confidence: 99%

The development of two white Plymouth Rock lines resistant to Marek's disease by breeding from survivors¹

et al. 1981

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SUMMARYA programme to develop resistance to Marek's disease (MD) in chickens in two non-inbred White Plymouth Rock (WPR) lines by breeding from survivors was initiated in 1968 and since then nine generations have been produced. In each generation only sires and dams which survived heavy exposure to virulent MD virus (MDV), Dutch strain K, either by inoculation (for the first two generations) or by contact-exposure (for the following seven generations) were used.In this long term trial a high level of resistance to MD was reached within five generations; thereafter no marked further increase in resistance could be obtained. Susceptibility to MD, reflected by MD mortality in each generation, was expressed as % incidence of MD.Statistical evaluation of MD susceptibility in the nine generations of the two lines revealed a significant interaction between MD mortality and two sources of variation, sex and generation. No overall line effect was found, but there was a significant line x generation interaction. The remaining interactions were not significant. Results indicate that breeding from survivors for development of resistance to MD is feasible. Exposure of birds to either artificial (by injection) or

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“…Cell cultures DEF were prepared from embryos incubated for 13 days. 5 ml of 10 6 cells/ml were seeded per 6 cm petri dish in growth medium (Rispens et al, 1969) and grown at 38.8°C in a CO 2 incubator. After 24 hours, cultures were employed for virus titration or isolation using maintenance medium (Rispens et al, 1969).…”

Section: Chickensmentioning

confidence: 99%

Quantitative pathogenicity of Marek's disease virus and vaccine virus strains in chickens: Macroscopical aspects

Maas¹,

Orthel²,

Rispens³

et al. 1978

Avian Pathology

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SUMMARYTwo virulent strains (JM and K) and one vaccine strain (CVI 988) of Marek's disease virus (MDV), together with two vaccine strains of the herpesvirus of turkeys (HVT) (FC 126 and PB-THV 1), all in the cellassociated state, were administered intramuscularly at 3.7 log TCID 50 per dose to day-old SPF White Leghorn chickens. A control group of chicks received uninfected cells.The pathological parameters studied were onset and duration of clinical symptoms, mortality, bird weight and macroscopical lesions of peripheral nerves and visceral organs. Data were obtained from females autopsied at the age of 3, 8 and 20 weeks, and from chickens which died. Virological and serological data were procured mainly from males taken at various ages.The results indicate a clear distinction between virulent and vaccine strains. MD vaccines had no significant influence on bird weight and caused no mortality or macroscopical lesions, whereas the virulent MDV strains produced all these effects. Macroscopical lesions caused by the virulent MDV strains were seen predominantly in nerves (in about 50% of birds succumbing to MD) and gonads (in 0% to 80% of such birds depending on sex and on strain of MDV). Differences between the two virulent strains could be demonstrated. Strain JM induced earlier incidence and shorter duration of clinical disease. With strain JM death occurred earlier in females than in males. Strain K caused significantly more macroscopical lesions in gonads, heart and liver.

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Some Virological and Serological Observations On Marek’s Disease: A Preliminary Report

Cited by 27 publications

References 5 publications

Age related resistance to avian leukosis virus. III. Infectious virus, neutralising antibody and tumours in chickens inoculated at various ages

Age related resistance to avian leukosis virus. III. Infectious virus, neutralising antibody and tumours in chickens inoculated at various ages

The development of two white Plymouth Rock lines resistant to Marek's disease by breeding from survivors¹

Quantitative pathogenicity of Marek's disease virus and vaccine virus strains in chickens: Macroscopical aspects

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Some Virological and Serological Observations On Marek’s Disease: A Preliminary Report

Cited by 27 publications

References 5 publications

Age related resistance to avian leukosis virus. III. Infectious virus, neutralising antibody and tumours in chickens inoculated at various ages

Age related resistance to avian leukosis virus. III. Infectious virus, neutralising antibody and tumours in chickens inoculated at various ages

The development of two white Plymouth Rock lines resistant to Marek's disease by breeding from survivors1

Quantitative pathogenicity of Marek's disease virus and vaccine virus strains in chickens: Macroscopical aspects

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The development of two white Plymouth Rock lines resistant to Marek's disease by breeding from survivors¹