Somesthetic, gustatory, olfactory function and salivary flow in patients with neuropathic trigeminal pain

Siviero, Mariana; Teixeira, Manoel Jacobsen; Siqueira, José Tadeu Tesseroli de; Siqueira, Sílvia Regina Dowgan Tesseroli de

doi:10.1111/j.1601-0825.2010.01660.x

Cited by 45 publications

(91 citation statements)

References 19 publications

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“…Thermal testing 14 was performed using the Thermosensi II electric test device (Functional Neurosurgery Division -Hospital das Clínicas, College School, São Paulo University, Brazil). The baseline temperature was 32ºC, and the contact square area of the thermode was 10x10 mm.…”

Section: Thermal Detectionmentioning

confidence: 99%

“…Mechanical/tactile and pain perception Touch perception 14 was assessed using a set of standardized vonFrey filaments with rounded tips of 0.5 mm diameter (g/mm 2 ) -IITC, WoodlandHills, USA. The mechanical pain detection was performed with standard pinpricks with 24 mm of length and 0.40 mm of diameter applied with an electronic device (g/mm 2 ) -Micromar ® , Diadema, São Paulo, Brazil.…”

Section: Thermal Detectionmentioning

confidence: 99%

“…Superficial algometry 14 was tested using disposable needles of 8x10x0.5 mm, which were applied with an electronic device with increasing force (Micromar ® , Diadema, São Paulo, Brazil). Three measurements in g/mm 2 were performed and the means and standard deviations were considered for the analysis.…”

Section: Superficial Pain Thresholdsmentioning

confidence: 99%

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Quantitative sensory testing in trigeminal traumatic neuropathic pain and persistent idiopathic facial pain

Siqueira

Siviero

Alvarez

et al. 2013

Arq. Neuro-Psiquiatr.

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The objective of this article was to investigate, with a systematic protocol of quantitative sensory testing, patients with persistent idiopathic facial pain (PIFP) and others with trigeminal traumatic neuropathic pain (TTN) compared to controls. Thirty patients with PIFP, 19 with TTN, and 30 controls were evaluated on subjective numbness and dysesthesia and with a systematic protocol of quantitative sensory testing for thermal evaluation (cold and warm), mechanical detection (touch and pinpricks for mechanical pain), superficial pain thresholds, and corneal reflex. We found that PIFP and TTN had numbness and dysesthesia higher than controls (p<0.001 and p=0.003), and that in both of them mechanical pain by pinpricks detection was abnormal intra and extra orally at the mandibular branch (p<0.001). Cold, warm, and tactile detections and pain thresholds were similar among the groups. Corneal reflex was abnormal in TTN (p=0.005). This study supports neuropathic mechanisms involving pain processing in PIFP and that the criterion on absence of sensorial variations in PIFP should be revised.

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Section: Thermal Detectionmentioning

confidence: 99%

Section: Thermal Detectionmentioning

confidence: 99%

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Quantitative sensory testing in trigeminal traumatic neuropathic pain and persistent idiopathic facial pain

Siqueira

Siviero

Alvarez

et al. 2013

Arq. Neuro-Psiquiatr.

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show abstract

“…On the basis of previous findings that pain was associated with elevated olfactory thresholds in the absence of diabetes [43], Brady et al [19] sought to assess the potential impact of neurological pain caused by diabetic peripheral neuropathy on olfactory function. The study showed that those with neuropathic pain experienced loss of general olfaction, and had reduced odour detection thresholds, reduced discrimination between odour qualities, reduced odour identification, and increased thresholds for odour intensity [19], in line with some previous findings [13,14].…”

Section: Olfactory Dysfunction and Diabetes Complicationsmentioning

confidence: 99%

Association between diabetes mellitus and olfactory dysfunction: current perspectives and future directions

et al. 2017

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The increasing global prevalence of diabetes mellitus presents a significant challenge to healthcare systems today. Although diabetic retinopathy, nephropathy and neuropathy are well-established complications of diabetes, there is a paucity of research examining the impact of dysglycaemia on the olfactory system. Olfaction is an important sense, playing a role in the safety, nutrition and quality of life of an individual, but its importance is often overlooked when compared with the other senses. As a result, olfactory dysfunction is often underdiagnosed. The present review article aims to present and discuss the available evidence on the relationship between diabetes and olfaction. It also explores the associations between olfactory dysfunction and diabetes complications that could explain the underlying pathogenesis. Finally, it summarizes the putative pathological mechanisms underlying olfactory dysfunction in diabetes that require further investigation.

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“…It has been more recently supported by many clinical articles showing abnormal gustative and olfactory functions in patients with orofacial neuropathic pain. 11,31 There is ample evidence of sensorial interaction between the trigeminal gustative and olfactory systems, which can be demonstrated by the convergence of inputs at the solitary tract, at the trigeminal complex, and in other subcortical areas. MVD is known as a procedure with little impact on facial sensitivity and few numbness complaints.…”

mentioning

confidence: 99%

Sensory abnormalities and masticatory function after microvascular decompression or balloon compression for trigeminal neuralgia compared with carbamazepine and healthy controls

Ichida

Almeida

Nóbrega

et al. 2015

JNS

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There is a lack of comparative papers regarding the outcomes of neurosurgery in patients with iTN. The objective of this study was to investigate sensory thresholds and masticatory function in 78 patients with iTN who underwent microvascular decompression (MVD) or balloon compression (BC), and compare these treatments with carbamazepine and 30 untreated healthy controls. methods The authors conducted a case-controlled longitudinal study. Patients were referred to 1 of 3 groups: MVD, BC, or carbamazepine. All patients were evaluated before and after treatment with a systematic protocol composed of a clinical orofacial questionnaire, Research Diagnostic Criteria for temporomandibular disorders, Helkimo indices, and a quantitative sensory-testing protocol (gustative, olfactory, cold, warm, touch, vibration, superficial, and deep pain thresholds). results Both MVD and BC were effective at reducing pain intensity (p = 0.012) and carbamazepine doses (p < 0.001). Myofascial and articular complaints decreased in both groups (p < 0.001), but only the patients in the MVD group showed improvement in Helkimo indices (p < 0.003). Patients who underwent MVD also showed an increase in sweet (p = 0.014) and salty (p = 0.003) thresholds. The sour threshold decreased (p = 0.003) and cold and warm thresholds increased (p < 0.001) in patients after MVD and BC, but only the patients who underwent BC had an increase in touch threshold (p < 0.001). coNclusioNs Microvascular decompression and BC resulted in a reduction in myofascial and jaw articular complaints, and the impact on masticatory function according to Helkimo indices was greater after BC than MVD. MVD resulted in more gustative alterations, and both procedures caused impairment in thermal thresholds (warm and cold). However, only BC also affected touch perception. The sensorial and motor deficits after BC need to be included as targets directly associated with the success of the surgery and need to be assessed and relieved as goals in the treatment of iTN.

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Somesthetic, gustatory, olfactory function and salivary flow in patients with neuropathic trigeminal pain

Abstract: All groups showed abnormal thresholds of gustation and olfaction; somesthetic findings were discrete in ITN and more common in PHN and BMS; central mechanisms of balance of sensorial inputs might be underlying these observations.

Cited by 45 publications

References 19 publications

Quantitative sensory testing in trigeminal traumatic neuropathic pain and persistent idiopathic facial pain

Quantitative sensory testing in trigeminal traumatic neuropathic pain and persistent idiopathic facial pain

Association between diabetes mellitus and olfactory dysfunction: current perspectives and future directions

Sensory abnormalities and masticatory function after microvascular decompression or balloon compression for trigeminal neuralgia compared with carbamazepine and healthy controls

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