Sonchus arvensis L. water extract attenuates dextran sulfate sodium-induced colitis by adjusting gut microbiota

Ren, Yachao; Hou, Shenghua; Sui, Yilei; Chang, Naidan; Zhou, Yue; Sun, Chongde

doi:10.1016/j.heliyon.2023.e14168

Cited by 1 publication

(1 citation statement)

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“…Natural extract from medicinal plants/herbs have become an important complementary treatment for UC [ 26 ]. Previously, we demonstrated that S. arvensis L. extract had a protective effect against DSS-induced UC in mice [ 27 ]. Flavones are major constituents of S. arvensis L. extract.…”

Section: Discussionmentioning

confidence: 99%

Total flavones from Sonchus arvensis L. ameliorate colitis by adjusting the gut microbiota

Ren,

Hou,

et al. 2023

Annals of Medicine

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Objective Sonchus arvensis L. is traditional Chinese food and medicine. We investigated protective effects of flavones from Sonchus arvensis L. (SAF) on colitis induced by dextran sulfate sodium (DSS) in mice by regulating gut microbiota (GM). Method C57BL/6 mice were divided randomly: control group (CL); DSS group (ML); positive control + DSS group (AN); SAF + DSS (FE) group. The protective effects of SAF on ulcerative colitis (UC) were estimated by food intake, water intake, bodyweight loss, diarrhea, blood in stools, colon length, histology, disease activity index (DAI) score, and blood parameters. The sequencing of 16S rRNA gene was detected to investigate effect of SAF on GM. Results SAF attenuate bodyweight loss significantly. The DAI score was lower in FE group than that in ML group. Colon length was improved significantly in ML group. Pathologic changes could be ameliorated after SAF was administered to UC mice. SAF improved blood parameters of model mice. 16S rRNA sequencing revealed that it was very important to ameliorate colitis with bacteria of the phylum Verrucomicrobiota, class Verrucomicrobiae, order Verrucomicrobiales, family Akkermansiaceae, and genus Akkermansia . Conclusion The SAF protective effect against colitis induced by DSS in mice may have a connection with GM diversity.

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Section: Discussionmentioning

confidence: 99%