Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos

“…The sonic hedgehog pathway (Shh) plays an important role in dorsal-ventral patterning of the cranial neural tube (Echelard et al, 1993). Shh is expressed in the floor plate and the underlying notochord, and this secreted signaling molecule is required for induction of ventral neural cell types (Wilson and Maden, 2005).…”

The hedgehog signalling pathway in tumorigenesis and development

“…While there is only a single Drosophila hedgehog gene, three vertebrate homologues have been identi®ed, Sonic (Shh), Desert (Dhh), and Indian hedgehog (Ihh) (Echelard et al, 1993). In vitro studies suggest that each of these proteins can act through the same signal transduction pathway, and that the di erent hedgehog genes regulate patterning of di erent organ systems by virtue of their unique expression pattern (Echelard et al, 1993;Marigo et al, 1996;Stone et al, 1996).…”

“…While there is only a single Drosophila hedgehog gene, three vertebrate homologues have been identi®ed, Sonic (Shh), Desert (Dhh), and Indian hedgehog (Ihh) (Echelard et al, 1993). In vitro studies suggest that each of these proteins can act through the same signal transduction pathway, and that the di erent hedgehog genes regulate patterning of di erent organ systems by virtue of their unique expression pattern (Echelard et al, 1993;Marigo et al, 1996;Stone et al, 1996). The most extensively studied of the vertebrate hedgehog genes is Shh which is expressed widely throughout the developing CNS, limb, lung, gut, teeth and hair-follicle (Bellusci et al, 1997;Hardcastle et al, 1998;Litingtung et al, 1998;Marigo and Tabin, 1996;Riddle et al, 1993;St-Jacques et al, 1998).…”

Activation of the hedgehog-signaling pathway in human cancer and the clinical implications

“…In the early 1990s, three homologs of the Hh gene were identified in vertebrates (Echelard et al, 1993;Krauss et al, 1993;Riddle et al, 1993;Chang et al, 1994;Roelink et al, 1994). As an essential developmental signaling pathway, the Hh pathway is critical for maintaining tissue polarity and stem cell population.…”