2018
DOI: 10.1007/s00383-018-4406-2
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Sonic hedgehog signaling controls gut epithelium homeostasis following intestinal ischemia–reperfusion in a rat

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Cited by 14 publications
(13 citation statements)
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“…The purpose of this study was to evaluate the role of BMP signaling during intestinal recovery following intestinal IR in a rat model. Similar to our previous experiments, 8,18 we have demonstrated in the current study that 24 hours following intestinal IR injury experimental rats demonstrated a significant increase in intestinal injury score that was accompanied by an intestinal mucosal hypoplasia. This is evident from a significant decrease in bowel weight and mucosal weight as well as a trend toward decrease in villus height and crypt depth.…”
Section: Discussionsupporting
confidence: 91%
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“…The purpose of this study was to evaluate the role of BMP signaling during intestinal recovery following intestinal IR in a rat model. Similar to our previous experiments, 8,18 we have demonstrated in the current study that 24 hours following intestinal IR injury experimental rats demonstrated a significant increase in intestinal injury score that was accompanied by an intestinal mucosal hypoplasia. This is evident from a significant decrease in bowel weight and mucosal weight as well as a trend toward decrease in villus height and crypt depth.…”
Section: Discussionsupporting
confidence: 91%
“…18 However, 48 hours after IR injury, intestinal epithelial cell proliferation was increased, suggesting tissue repair. 8 This increase in cell proliferation was accompanied by increased cell apoptosis suggesting accelerated intestinal epithelial cell turnover probably due to activated intestinal stem cell activity.…”
Section: Discussionmentioning
confidence: 98%
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“…[ 22 ] Meanwhile, intestinal recovery was correlated with an increase in Shh signaling pathway activity in intestinal ischemia‐reperfusion. [ 23 ]…”
Section: Resultsmentioning
confidence: 99%
“…They are also involved in normal gut development. These signaling pathways include Wnt/β-catenin, Hedgehog, Bone morphogenetic protein (BMP) and Notch [9]. Our research group has demonstrated that 24h following IR, Hedgehog [10] and BMP [11] signaling pathways were inhibited, which correlated with inhibited cell turnover.…”
Section: Academic Journal Of Pediatrics and Neonatologymentioning
confidence: 99%