Sonneradon A Extends Lifespan of Caenorhabditis elegans by Modulating Mitochondrial and IIS Signaling Pathways

Jiang, Shu; Jiang, Cuiping; Cao, Pei; Liu, Yonghong; Gao, Chenghai; Yi, Xiangxi

doi:10.3390/md20010059

Cited by 12 publications

(3 citation statements)

References 49 publications

(58 reference statements)

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“…Sonneradon A ( 282 ), isolated from the edible fruits of mangrove Sonneratia apetala , showed remarkable antiaging activity, which inhibited production of reactive oxygen species (ROS) by 53%, and reduced the accumulation of aging markers such as lipids and lipofuscins [ 77 ]. Three new chlorinated orsellinic aldehyde derivatives, orsaldechlorins A–C ( 283 – 285 ) and a naturally new brominated orsellinic acid ( 286 ), were identified from the Beibu Gulf coral-derived fungus Acremonium sclerotigenum GXIMD 02501.…”

Section: New Mnps From the Beibu Gulfmentioning

confidence: 99%

Marine Natural Products from the Beibu Gulf: Sources, Chemistry, and Bioactivities

et al. 2023

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Marine natural products (MNPs) play an important role in the discovery and development of new drugs. The Beibu Gulf of South China Sea harbors four representative marine ecosystems, including coral reefs, mangroves, seaweed beds, and coastal wetlands, which are rich in underexplored marine biological resources that produce a plethora of diversified MNPs. In our ongoing efforts to discover novel and biologically active MNPs from the Beibu Gulf, we provide a systematic overview of the sources, chemical structures, and bioactive properties of a total of 477 new MNPs derived from the Beibu Gulf, citing 133 references and covering the literature from the first report in November 2003 up to September 2022. These reviewed MNPs were structurally classified into polyketides (43%), terpenoids (40%), nitrogen-containing compounds (12%), and glucosides (5%), which mainly originated from microorganisms (52%) and macroorganisms (48%). Notably, they were predominantly found with cytotoxic, antibacterial, and anti-inflammatory activities. This review will shed light on these untapped Beibu Gulf-derived MNPs as promising lead compounds for the development of new drugs.

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Section: New Mnps From the Beibu Gulfmentioning

confidence: 99%

Marine Natural Products from the Beibu Gulf: Sources, Chemistry, and Bioactivities

et al. 2023

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“…To date, the heat shock genes (hsp genes) and the Hsp proteins they encode have been best studied and described in the free-living bacterivorous nematode Caenorhabditis elegans (Maupas, 1900). Studies have shown that the expression of hsp genes influences the lifespan of C. elegans [6][7][8]. It has also been shown that hsp genes in C. elegans are induced in response to various stressors, such as oxidative stress [9][10][11], electromagnetic field [12][13][14], immunological stress [15][16][17], or toxic chemical compounds [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Temperature Effects on Expression Levels of hsp Genes in Eggs and Second-Stage Juveniles of Meloidogyne hapla Chitwood, 1949

Flis,

Malewski,

Dobosz

2024

IJMS

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Meloidogyne hapla is one of the most important nematode pathogens. It is a sedentary, biotrophic parasite of plants that overwinters in the soil or in diseased roots. The development of M. hapla is temperature dependent. Numerous studies have been performed on the effect of temperature on the development of M. hapla, but only a few of them analyzed the heat shock protein (hsp) genes. The aim of the study was to perform expression profiling of eight hsp genes (Mh-hsp90, Mh-hsp1, Mh-hsp4, Mh-hsp6, Mh-hsp60, Mh-dnj19, Mh-hsp43, and Mh-hsp12.2) at two development stages of M. hapla, i.e., in eggs and second-stage juveniles (J2). The eggs and J2 were incubated under cold stress (5 °C), heat stress (35 °C, 40 °C), and non-stress (10 °C, 20 °C, and 30 °C) conditions. Expression profiling was performed by qPCR. It was demonstrated that only two genes, Mh-hsp60 and Mh-dnj19, have been upregulated by heat and cold stress at both development stages. Heat stress upregulated the expression of more hsp genes than cold stress did. The level of upregulation of most hsp genes was more marked in J2 than in eggs. The obtained results suggest that the Mh-hsp90 and Mh-hsp1 genes can be used as bioindicators of environmental impacts on nematodes of the Meloidogyne genus.

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“…The fruit contains a high content of nutrients, polyphenols, flavonoids, vitamin C, and antioxidants. The fruit exhibits the following health-promoting activities: anti-diarrheal, analgesic, hepatoprotective, anti-aging, and inhibition of elastase-induced lung injury ( Hossain et al, 2016a , 2017 ; Liu et al, 2019 ; Yi et al, 2020 ; Jiang et al, 2022 ; Sengupta et al, 2022 ). Moreover, S. apetala fruit is second to Emblica officinalis in its content of polyphenols [48 mg gallic acid equivalent (GAE)/g powder] among the edible fruits in Bangladesh ( Hosen et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Sonneratia apetala (Buch.-Ham.) Fruit Extracts Ameliorate Iron Overload and Iron-Induced Oxidative Stress in Mice

Mithila,

Islam,

Khatun

et al. 2023

Prev. Nutr. Food Sci.

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Iron overload results in oxidative damage to various biomolecules including DNA, proteins and lipids which ultimately leads to cell death. The Sonneratia apetala fruit contains a high content of antioxidants and displays several bioactive properties. Therefore, the powder of the S. apetala fruit was successively fractionated into n -hexane (Hex), chloroform (Chl), and methanol (Met) fractions to evaluate their efficiency in ameliorating iron overload. In vitro , a colorimetric method was used to assess the Fe-chelating activity of the fractions using ferrozine. The fractions were also used in vivo to examine their efficacy in ameliorating iron overload and iron-induced oxidative stress in mice induced by intraperitoneal injection of ferric carboxymaltose at 100 mg/kg body weight (bw). Among the fractions, Met showed the highest Fe-chelation ability with an inhibitory concentration 50 of 165 μg/mL followed by Hex (270 μg/mL), and Chl (418 μg/mL). In vivo , the results showed a significantly ( P <0.05) lower iron profile (iron and ferritin concentrations in serum and liver tissue and total iron-binding capacity of serum) in the Met and the Hex treated mice groups than in the iron-overloaded group. Met at 1,000 μg/kg bw completely ameliorated iron overload in the blood and the liver tissue of mice. At this concentration, Met also prevented iron-induced oxidative stress in the liver tissue of iron-overloaded mice by restoring reducing power, total antioxidant capacity, and total protein. Thus, the S. apetala fruit, especially its Met fraction can be used in treating iron overload and associated toxicity.

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Sonneradon A Extends Lifespan of Caenorhabditis elegans by Modulating Mitochondrial and IIS Signaling Pathways

Cited by 12 publications

References 49 publications

Marine Natural Products from the Beibu Gulf: Sources, Chemistry, and Bioactivities

Marine Natural Products from the Beibu Gulf: Sources, Chemistry, and Bioactivities

Temperature Effects on Expression Levels of hsp Genes in Eggs and Second-Stage Juveniles of Meloidogyne hapla Chitwood, 1949

Sonneratia apetala (Buch.-Ham.) Fruit Extracts Ameliorate Iron Overload and Iron-Induced Oxidative Stress in Mice

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