2020
DOI: 10.1002/slct.202002951
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Sonochemical Synthesis of 6‐Substituted Indolo[3′,2′:4,5]pyrrolo[2,3‐b]quinoxaline Derivatives as Potential Cytotoxic Agents

Abstract: In the current study, we have explored 6‐substituted indolo[3′,2′:4,5]pyrrolo[2,3‐b]quinoxaline derivatives as potential cytotoxic agents. These compounds were readily prepared via the reaction of 2‐chloro‐3‐(2‐chloro‐1H‐indol‐3‐yl)quinoxaline with an appropriate amine under ultrasound irradiation in good to acceptable yields. The in vitro testing of all these compounds against MDA‐MB‐231 and MCF‐7 cell lines using a cell‐based assay and then against SIRT1 (or sirtuin 1) using an enzyme‐based assay was perform… Show more

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Cited by 3 publications
(1 citation statement)
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“…Studies on the inhibition of the SIRT1 enzyme had reported by several previous studies using in vitro approach. [12][13][14][15][16] One of them was 4-(4-(2-[(methylsulfonyl)amino]ethyl)piperidin-1-yl) thieno [3,2-d]pyrimidine-6-carboxamide had known can inhibit the SIRT1 enzyme with IC 50 value 4 nM. 16 Additionally, stilbenoid derivatives showed SIRT1 (IC 50 mM) enzyme inhibitory activity, such as stilbenoid dimer ((À)-ampelopsin F: 24.4 mM) and stilbenoid tetramer ((+)-vitisin A: 22.0 mM, (À)-vitisin B: 21.1 mM, (+)-hopeaphenol: 3.45 mM, (À)-hopeaphenol: 18.1 mM, and (À)-isohopeaphenol: 21.6 mM).…”
Section: Introductionmentioning
confidence: 99%
“…Studies on the inhibition of the SIRT1 enzyme had reported by several previous studies using in vitro approach. [12][13][14][15][16] One of them was 4-(4-(2-[(methylsulfonyl)amino]ethyl)piperidin-1-yl) thieno [3,2-d]pyrimidine-6-carboxamide had known can inhibit the SIRT1 enzyme with IC 50 value 4 nM. 16 Additionally, stilbenoid derivatives showed SIRT1 (IC 50 mM) enzyme inhibitory activity, such as stilbenoid dimer ((À)-ampelopsin F: 24.4 mM) and stilbenoid tetramer ((+)-vitisin A: 22.0 mM, (À)-vitisin B: 21.1 mM, (+)-hopeaphenol: 3.45 mM, (À)-hopeaphenol: 18.1 mM, and (À)-isohopeaphenol: 21.6 mM).…”
Section: Introductionmentioning
confidence: 99%