“…Studies on the inhibition of the SIRT1 enzyme had reported by several previous studies using in vitro approach. [12][13][14][15][16] One of them was 4-(4-(2-[(methylsulfonyl)amino]ethyl)piperidin-1-yl) thieno [3,2-d]pyrimidine-6-carboxamide had known can inhibit the SIRT1 enzyme with IC 50 value 4 nM. 16 Additionally, stilbenoid derivatives showed SIRT1 (IC 50 mM) enzyme inhibitory activity, such as stilbenoid dimer ((À)-ampelopsin F: 24.4 mM) and stilbenoid tetramer ((+)-vitisin A: 22.0 mM, (À)-vitisin B: 21.1 mM, (+)-hopeaphenol: 3.45 mM, (À)-hopeaphenol: 18.1 mM, and (À)-isohopeaphenol: 21.6 mM).…”