Sonochemical synthesis of rosuvastatin based novel 3-methyleneisoindolin-1-one derivatives as potential anticancer agents

Kumar, J.S. Dileep; Reddy, Gangireddy Sujeevan; Medishetti, Raghavender; Ray, Arnab; Bele, Shilpak Dilip; Hossain, Kazi Amirul; Thirupataiah, B.; Edwin, Rebecca Kristina; Behera, Parameswar; Joseph, Alex; Shenoy, Gautham G.; Rao, C. Mallikarjuna; Pal, Manojit

doi:10.1016/j.molstruc.2021.130574

Cited by 9 publications

(2 citation statements)

References 39 publications

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“…The amount of apoptosis was increased by about 12 %, 43 %, and 40 % after treatment of compound 29 with 59.10 μM, 64.10 μM, and 69.10 μM, respectively in MCF-7 cells. [49]…”

Section: -(4-methylbenzyl)-4-nitrophenol Substituted Indole Derivativesmentioning

confidence: 99%

Indole Derived Anticancer Agents

et al. 2022

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Indole moiety is a magnificent nucleus in the development of anticancer drugs. The pharmacological profile of indole is excellent in targeting a wide range of proteins, enzymes. An indole has a nitrogen atom that is capable of forming hydrogen bonds with the targets emphasizing its potential. Many studies have demonstrated the effectiveness of indole in the treatment of cancer by working through various pathways. Indole-based drugs got market approval to be used as chemotherapeutics, such as vincristine and vinblastine which encourage researchers to work on indole derivatives for cancer treatment with a better pharmacokinetic profile. This prompted us to review on indole derivatives as anticancer agents to bring out their potential derivatives under study. This study encompasses literature published between 2014 and 2021 on indole scaffold that exhibits in vitro and in vivo potential against cancer by searching PubMed, Google Scholar, and Science Direct databases. The search terms were "anticancer", "indole", "cell lines", "structure-activity relationship" and "cytotoxic activity."[a] A.

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“…The amount of apoptosis was increased by about 12 %, 43 %, and 40 % after treatment of compound 29 with 59.10 μM, 64.10 μM, and 69.10 μM, respectively in MCF-7 cells. [49]…”

Section: -(4-methylbenzyl)-4-nitrophenol Substituted Indole Derivativesmentioning

confidence: 99%

Indole Derived Anticancer Agents

et al. 2022

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“…[14][15][16][17] Recent reports demonstrated that various substituted 3-methyleneisoindolin-1-ones and isoquinolin-1(2H)-ones have been generated in good yields in shorter reaction time via metal-catalyzed-cascade reaction (comprising of Sonogashira type coupling-heterocyclization reactions) under ultrasonic irradiation. [18][19][20] Due to these valuable features, the ultrasonic irradiation has been widely employed in organic synthesis and industrial process.…”

Section: Introductionmentioning

confidence: 99%