Sonochemically modified ovalbumin enhances enantioenrichment of some amino acids

Mutalikdesai, Amruta; Nassir, Molhm; Saady, Abed; Häßner, Alfred; Gedanken, Aharon

doi:10.1016/j.ultsonch.2019.05.020

“…It has proven to be a facile, cost-and timeeffective technique that enables highly efficient encapsulation of a variety of drugs/cargo in the shell, as well as the core of the capsules. Our group has utilized this technique to synthesize protein microcapsules of BSA [83], HSA, and egg albumin [84], encapsulating a variety of hydrophilic and hydrophobic cargo, including gemcitabine [20], ribonucleic acid (RNA) [16,35], rhodamine B [85], MSQ (12i) 1-methyl-4-(substituted) styryl-quinolinium derivative [85,86], etc. During ultrasonication-assisted emulsification, the size of the protein microspheres depends on the nature of the oil-water interface, viscosity, surface tension, and hydrophobicity of the organic phase.…”

Section: Emulsion-coacervationmentioning

confidence: 99%

Function of Polymers in Encapsulation Process

2022

0

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“…It has proven to be a facile, cost-and timeeffective technique that enables highly efficient encapsulation of a variety of drugs/cargo in the shell, as well as the core of the capsules. Our group has utilized this technique to synthesize protein microcapsules of BSA [83], HSA, and egg albumin [84], encapsulating a variety of hydrophilic and hydrophobic cargo, including gemcitabine [20], ribonucleic acid (RNA) [16,35], rhodamine B [85], MSQ (12i) 1-methyl-4-(substituted) styryl-quinolinium derivative [85,86], etc. [92].…”

Section: Emulsion-coacervationmentioning

confidence: 99%

Designing Natural Polymer-Based Capsules and Spheres for Biomedical Applications—A Review

Sharma

¹

,

Porat

²

,

Gedanken

³

2021

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Natural polymers, such as polysaccharides and polypeptides, are potential candidates to serve as carriers of biomedical cargo. Natural polymer-based carriers, having a core–shell structural configuration, offer ample scope for introducing multifunctional capabilities and enable the simultaneous encapsulation of cargo materials of different physical and chemical properties for their targeted delivery and sustained and stimuli-responsive release. On the other hand, carriers with a porous matrix structure offer larger surface area and lower density, in order to serve as potential platforms for cell culture and tissue regeneration. This review explores the designing of micro- and nano-metric core–shell capsules and porous spheres, based on various functions. Synthesis approaches, mechanisms of formation, general- and function-specific characteristics, challenges, and future perspectives are discussed. Recent advances in protein-based carriers with a porous matrix structure and different core–shell configurations are also presented in detail.

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Effects of sound energy on proteins and their complexes

Kozell,

Solomonov,

Shimanovich

2023

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Mechanical energy in the form of ultrasound, and protein complexes intuitively have been considered as two distinct unrelated topics. However, in the past few years, increasingly more attention has been paid to the ability of ultrasound to induce chemical modifications on protein molecules that further change protein‐protein interaction and protein self‐assembling behavior. Despite efforts to decipher the exact structure and the behavior‐modifying effects of ultrasound on proteins, our current understanding of these aspects remains limited. The limitation arises from the complexity of both phenomena. Ultrasound produces multiple chemical, mechanical, and thermal effects in aqueous media. Proteins are dynamic molecules with diverse complexation mechanisms. This review provides an exhaustive analysis of the progress made in better understanding the role of ultrasound in protein complexation. It describes in detail how ultrasound affects an aqueous environment and the impact of each effect separately and when combined with the protein structure and fold, the protein‐protein interaction, and finally the protein self‐assembly. It specifically focuses on modifying role of ultrasound in amyloid self‐assembly, where the latter is associated with multiple neurodegenerative disorders.

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Sonochemically modified ovalbumin enhances enantioenrichment of some amino acids

Cited by 8 publications

References 35 publications

Function of Polymers in Encapsulation Process

Function of Polymers in Encapsulation Process

Designing Natural Polymer-Based Capsules and Spheres for Biomedical Applications—A Review

Effects of sound energy on proteins and their complexes

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