Sonodynamic and Photodynamic Therapy in Breast Cancer - A Pilot Study

Abstract

In this exploratory pilot study, we investigated the potential efficacy of a new systemic tumor therapeutic method as a supplementary or salvage treatment in advanced refractory breast cancer. Termed Sono-Photo Dynamic Therapy (SPDT), this technology utilizes full body and targeted ultrasound in conjunction with photodynamic therapy. Twelve patients with advanced breast carcinoma participated, eleven with metastases in the viscera and brain, and nine within bone. Nine patients had concurrent low dose chemotherapy with the SPDT. After the first round of treatment (where the number of cycles of SPDT varied from 1-4), the overall response rate was 75% (two patients achieved Complete Response [16.67%] and seven patients achieved Partial Response [58.33%]). Results suggest that SPDT was not associated with serious side effects, and may enhance chemotherapy efficacy in the treatment of advanced refractory breast cancer. Despite the exploratory nature of this study, the results suggest that SPDT shows promise as a new systemic approach for tumor adjunct therapy and merits further investigation.

Important Advances in Antibacterial Nanoparticle-Mediated Photodynamic Therapy

“…The exploratory clinical study of PDT combined with sonodynamic therapy (SDT) against cholangiocarcinoma in which hematoporphyrin was used as the sono-photosensitizer provides a clear indication of the state of this technology in the clinical translation trajectory [117]. This is supported by the clinical pilot studies [118] and case reports [119] that are starting to appear in the literature. Nanotechnology is ubiquitous not only as a platform for the PDT and SDT agents [120,121], but also for other purposes of the innovation, such as hypoxia amelioration, disease targeting, imaging-guided therapy, and stimulus-responsive release.…”

Hypoxia-Adapted Sono-chemodynamic Treatment of Orthotopic Pancreatic Carcinoma Using Copper Metal–Organic Frameworks Loaded with an Ultrasound-Induced Free Radical Initiator

“…15 However, there have been relatively few studies indicating that introducing oxygen-independent USactivated free radical generators into the SDT treatment platform can improve therapeutic outcomes in solid hypoxic tumors. 3 effectively with photodynamic therapy, 16,17 photothermal therapy, 14,18 chemotherapy, 19−21 and immunotherapy. 22,23 The use of metal−organic frameworks (MOFs) as delivery vehicles for different pharmacological agents has been found to be highly effective because of the robust drug-loading capacity and controlled drug relief properties of these nanomaterials.…”

“…However, there have been relatively few studies indicating that introducing oxygen-independent US-activated free radical generators into the SDT treatment platform can improve therapeutic outcomes in solid hypoxic tumors . SDT approaches have also been shown to synergize effectively with photodynamic therapy, , photothermal therapy, , chemotherapy, − and immunotherapy. , …”